Effects of Asymmetries on Binaural-Hearing Abilities Across the Lifespan
试验速览
- 阶段
- 不适用
- 状态
- Enrolling By Invitation
- 入组人数
- 150
- 试验地点
- 1
- 主要终点
- Sound localization
研究概览
简要总结
Binaural hearing involves combining auditory information across the ears. With binaural hearing, listeners benefit from perceiving sounds from different spatial locations. This is critical in solving the "cocktail party problem" (i.e., understanding speech in the presence of competing background sounds and noise). As humans get older, hearing loss increases, binaural abilities decrease, and the cocktail party problem becomes increasingly difficult. This research studies the mechanisms underlying the impact of age and hearing loss on speech-perception in noise and cocktail-party listening situations. More specifically, the role of hearing asymmetries between the ears is investigated. The specific aims are to generate an audiological and binaural-hearing-focused dataset for a large cohort of participants that vary in hearing asymmetry, age, and hearing loss and to use machine learning to uncover complex associations and generate novel hypotheses relating audiometric variables and basic binaural-hearing abilities to the cocktail-party problem. Participants in this research will complete perceptual measures of hearing acuity and spatial hearing. Participants will also report on speech understanding under noisy and challenging listening conditions. This research may lead to improvements in audiological care and hearing interventions.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Adults (18-80 years)
- •No hearing asymmetry between ears (≤10 dB at any frequency) or, hearing asymmetry between ears >10 dB
- •Native English speakers
- •Primarily use oral language
- •Sufficient corrected or uncorrected visual acuity (20/50 or better) to read large-font text
排除标准
- •Acoustic tone-detection threshold >50 dB HL at any octave frequency (250-4000 Hz) in either ear (i.e., more than a moderate hearing loss)
- •History of neurological disorders (e.g., stroke, Parkinson's disease) determined by self-report
- •History of post-traumatic stress disorder or traumatic brain injury determined by self-report
- •Possibility of acoustic neuroma, hearing asymmetry (>10 dB at three consecutive audiometric threshold frequencies)
- •Montreal Cognitive Assessment (MoCA) score <22/30
- •No oral language use
- •Cochlear implant user
- •Conductive hearing loss
研究组 & 干预措施
Test of Hearing Function in Acoustic Hearing Listeners
干预措施: Test of hearing function (Diagnostic Test)
结局指标
主要结局
Sound localization
时间窗: After enrollment, in one visit lasting 1-2 hours
A measure of sound localization ability (summarizing the ability using broadband and narrowband noise stimuli). Localization is the ability to accurately report the location from which a sound source originated. The difference between actual and reported locations is used for the measure. (Units, angle measure in degrees)
Spatial release from masking
时间窗: After enrollment, in one visit lasting 1-2 hours
A measure of speech understanding. Spatial release from masking is calculated by finding the difference in thresholds between listening with co-located vs. separated masking signals. (Units, dB)
次要结局
- Basic binaural sensitivity(After enrollment, in one visit lasting 1-2 hours)
- Cognitive assessment(After enrollment, in one visit lasting 1-2 hours)
- Audiological assessment of hearing thresholds(After enrollment, in one visit lasting ~1 hour)
- Auditory Brainstem Response(After enrollment, in one visit lasting ~1 hour)
- Distortion-Product Otoacoustic Emissions(After enrollment, in one visit lasting ~1 hour)