临床试验/NCT00186225

NCT00186225已完成不适用

Stem Cell Transplantation From Matched Unrelated or Partially Matched Related Donors Using a Preparatory Regimen Consisting of Fractionated Total Body Irradiation (FTBI) and Cyclophosphamide (CY)

Stanford University2 个研究点分布在 1 个国家目标入组 250 人开始时间: 2005年9月16日最近更新: 2020年4月9日

适应症

试验速览

阶段: 不适用
状态: 已完成
发起方: Stanford University
入组人数: 250
试验地点: 2
主要终点: oxicity and efficacy of TBI and cyclophosphamide as preparation for hematopoietic cell transplantation from partially matched and unrelated donors.

研究概览研究设计入排标准结局指标研究者研究点记录与标识符相似试验

研究概览

简要总结

To evaluate the use of unrelated donors for hematopoietic cell transplantation in the treatment of hematologic and lymphoid malignancies.

详细描述

Stem Cell Transplantation from Matched Unrelated or Partially Matched Related Donors Using a Preparatory Regimen Consisting of Fractionated Total Body Irradiation (FTBI) and Cyclophosphamide (CY). To administer high dose radio-chemotherapy followed by stem cell transplantation from a matched unrelated donor or a partially matched related donor.

研究设计

研究类型: Interventional
分配方式: Non Randomized
干预模型: Single Group
主要目的: Treatment
盲法: None

入排标准

年龄范围: 4 Weeks 至 50 Years（Child, Adult）
性别: All
接受健康志愿者: 否

入选标准

•acute leukemia
•chronic leukemia
•lymphoblastic lymphoma

排除标准

•organ dysfunction
•HIV positive

结局指标

主要结局

oxicity and efficacy of TBI and cyclophosphamide as preparation for hematopoietic cell transplantation from partially matched and unrelated donors.

次要结局

Overall Survival
Event Free Survival

研究者

发起方

Stanford University

申办方类型

Other

责任方

Sponsor

研究点 (2)

Loading locations...

相似试验

Unknown

不适用

Pilot Study of Unrelated Donor Hematopoietic Stem Cell Transplantation in Patients With Life Threatening Hemophagocytic DisordersChediak-Higashi SyndromeGraft Versus Host DiseaseX-Linked Lymphoproliferative SyndromeFamilial Erythrophagocytic LymphohistiocytosisVirus-Associated Hemophagocytic SyndromeHemophagocytic Lymphohistiocytosis

NCT00006056Fairview University Medical Center40

终止

2 期

NCT01050439Columbia University22

已完成

不适用

Conditioning Regimen Before Infusion of Allogeneic Hematopoietic Stem CellsHEMATOLOGIC MALIGNANCIES

NCT00770523Cooperative Study Group A for Hematology52

招募中

2 期

Allogeneic Hematopoietic Stem Cell Transplantation for Severe Aplastic Anemia and Other Bone Marrow Failure Syndromes Using G-CSF Mobilized CD34+ Selected Hematopoietic Precursor Cells Co-Infused With a Reduced Dose of Non-Mobilized Donor T-cellsMDS (Myelodysplastic Syndrome)Severe Aplastic Anemia

NCT01174108National Heart, Lung, and Blood Institute (NHLBI)120

终止

2 期

Donor Stem Cell Transplant or Donor White Blood Cell Infusions in Treating Patients With Hematologic CancerChronic Myeloproliferative DisordersMultiple Myeloma and Plasma Cell NeoplasmLymphomaLeukemiaMyelodysplastic SyndromesMyelodysplastic/Myeloproliferative NeoplasmsUnusual Cancers of Childhood

NCT00281879OHSU Knight Cancer Institute200