The Metabolic Response to Fructose Ingestion
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 8
- 试验地点
- 2
- 主要终点
- Changes in Circulating Levels of Soluble Leptin Receptor After Fructose Ingestion
研究概览
简要总结
The goal of this clinical trial is to learn how fructose ingestion affects metabolic factors in healthy adults aged 18-64, with a BMI between 19 and 30 kg/m², of any sex or gender. Specifically, the study aims to examine the impact of fructose compared to glucose on circulating metabolic factors including the soluble leptin receptor.
The main questions it aims to answer are:
How does fructose ingestion influence levels of circulating metabolic markers, including the soluble leptin receptor? Does fructose consumption have different metabolic effects compared to glucose?
Participants will:
Complete a screening phone call to review their health history and eligibility.
Attend two in-person visits at least two weeks apart, where they will:
Fast for 8 hours beforehand. Consume a beverage containing either 75g of fructose or glucose. Have blood drawn at regular intervals for up to 5 hours after consumption to measure circulating levels of metabolic markers.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 64 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Age: Participants must be between 18 and 64 years old.
- •BMI: Participants must have a Body Mass Index (BMI) between 19 and 30 kg/m² (healthy weight to slightly overweight).
- •Health Status: Participants must be healthy volunteers with no significant medical conditions.
- •Sex/Gender: Both males and females are eligible to participate.
排除标准
- •Known significant medical illness, any medications except oral contraceptives, history of fructose intolerance, pregnancy. We will not enroll BCM Medical students or individuals who work directly for any of the study investigators.
结局指标
主要结局
Changes in Circulating Levels of Soluble Leptin Receptor After Fructose Ingestion
时间窗: From baseline (Day 0) to 300 minutes post-ingestion.
The study will measure changes in the blood levels of soluble leptin receptor (ng/mL) following fructose ingestion. These levels will be assessed at multiple time points-baseline (0 minutes), 30 minutes, 60 minutes, 120 minutes, 180 minutes, 240 minutes, and 300 minutes post-ingestion-to evaluate how fructose affects their concentrations compared to baseline levels and glucose ingestion.
次要结局
- Change in Circulating Levels of fibroblast growth factor 21(FGF 21)(From baseline (0 minutes) to 300 minutes post-ingestion.)
- Change in Circulating Insulin Levels(From baseline (0 minutes) to 300 minutes post-ingestion.)
- Change in Triglyceride Levels(From baseline (0 minutes) to 300 minutes post-ingestion.)
- Change in Cholesterol Levels(From baseline (0 minutes) to 300 minutes post-ingestion.)
研究者
Mark Andrew Herman
Associate Professor; Chief, Section of Endocrinology, Diabetes, and Metabolism, Medicine, Baylor College of Medicine
Baylor College of Medicine