Sleep-disordered Breathing After Solid Organ Transplantation
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 300
- 试验地点
- 1
- 主要终点
- Number of participants with SDB and type (central or obstructive) of SDB
研究概览
简要总结
Sleep-disordered breathing (SDB) describes a group of disorders in which partial or complete cessation of breathing occurs many times throughout the night, resulting in daytime sleepiness or fatigue that interferes with a person's ability to function and reduces quality of life. Transplantation has become an important treatment modality for end-stage organ failure. Transplant recipients are now living longer and, hence, develop chronic adverse medical conditions. Furthermore, transplantation is associated with weight gain. Despite the high prevalence of poor sleep and cardiovascular conditions among transplant patients, SDB is not well studied in these patients.
详细描述
The primary research objective is to evaluate the prevalence, incidence and type (central or obstructive) of SDB in patients after lung transplantation.
Secondary research objectives are the evaluation of correlations between severity of SDB and clinical findings (weight, medical therapy, heart function, lung function, renal function, graft failure, ...). Furthermore, the investigators will evaluate the relationship between SDB and cardiovascular morbidity.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients 1 year after lung transplantation
排除标准
- •Refusal of PSG
- •Medical contra-indication to perform PSG
结局指标
主要结局
Number of participants with SDB and type (central or obstructive) of SDB
时间窗: 1 year after lung transplantation
Prevalence of different types of SDB after lung transplantation
次要结局
- Lung function measurement(1 year after lung transplantation)
- Blood analysis(1 year after lung transplantation)
- 24h blood pressure(1 year after lung transplantation)
- Echocardiography(1 year after lung transplantation)