NCT06786754Enrolling By Invitation不适用
FIBROBLASTS AND THORACIC AORTIC ANEURYSMS: IN VITRO CHARACTERIZATION IN PATIENTS WITH MARFAN SYNDROME AND GENETIC AORTIC DISEASES
IRCCS Policlinico S. Donato2 个研究点 分布在 1 个国家目标入组 15 人开始时间: 2025年6月17日最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- Enrolling By Invitation
- 发起方
- 入组人数
- 15
- 试验地点
- 2
- 主要终点
- Fibroblasts phenotype: cell morphology and migration
研究概览
简要总结
The aim of the present study is to characterise the phenotype of fibroblasts and to classify different mechanisms involved in the onset and progression of TAAD in syndromic and non-syndromic subjects in order to evaluate potential markers related to TAAD.
详细描述
The aim of the study is to analyse cutaneous fibroblast properties in patients with thoracic aortic aneurysms (both syndromic and non-syndromic) to identify differences in molecular mechanisms in collagen turnover pathways compared to healthy controls in the general population.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •(general for the study):
- •signed informed consent; subjects aged 18 years and above.
- •Inclusion Criteria (Case):
- •subjects with Marfan syndrome and thoracic aortic aneurysms (in clinical follow-up or with cardiac surgery program); subjects with non-syndromic thoracic aortic aneurysms (in clinical follow-up or with cardiac surgery program);
- •Inclusion Criteria (healthy controls):
- •absence of any aortic/thoracic disease;
排除标准
- •(all groups):
- •Presence of any confounding cardiovascular risk factor (hypertension, dyslipidaemia, diabetes, smoking habits) or previous cardiovascular disease
- •Corticosteroid or Steroids or Fluorochinolones treatment within six months before enrollment Subjects on chronic immunosuppressive therapies such as oral steroids, but also on chronic topical steroids in the area of investigation;
- •A history of keloid formation (data found in anamnesis and medical records);
- •Anaesthetic drug allergy (data found in anamnesis and medical records).
结局指标
主要结局
Fibroblasts phenotype: cell morphology and migration
时间窗: 12 months
cell morphology: phase-contrast microscopy
次要结局
- Levels of metalloproteinases involved in ECM degradation(24 months)
- Expression of genes and proteins involved in collagen turnover and extracellular matrix remodeling pathways(16 months)
研究者
Alessandro Pini
Principal Investigator
IRCCS Policlinico S. Donato
研究点 (2)
Loading locations...
相似试验
尚未招募
不适用
Molecular pathological study on fibroplastic lesions of the oral primary origin.Denture fibroma,Epuris,Lrritative fibroma,True fibromaJPRN-UMIN000031707Kanagawa Dental College65
招募中
Unknown
Analysis of inflammation and fibrosis mechanisms in eosinophilic esophagitis and esophageal motility disorders.Eosinophilic Esophagitis, Esophageal Achalasia, Esophageal Motility DisorderJPRN-UMIN000049850Chiba University100
已完成
不适用
68Ga-FAPI PET/CT to Detect Ongoing Fibroblast Activity in Post-acute COVID-19Post-Acute COVID-19Post-Acute COVID-19 InfectionPost-Acute COVID-19 SyndromePulmonary FibrosisNCT05981885University Medical Center Groningen18
已完成
不适用
FibroScan in Patients With Hepatitis B and C Presenting for Liver BiopsyHepatitis CHepatitis BCirrhosisNCT00125762Afdhal, Nezam, M.D.907
招募中
不适用
Evaluation of biomarkers indicating fibrotic activity in idiopathic pulmonary fibrosis and other diffuse parenchymal lung diseases.J84J43Other interstitial pulmonary diseasesEmphysemaDRKS00000017Abteilung für Pneumologie400