Platelet Indices in Patients Undergoing Primary Percutaneous Coronary Intervention :Its Relation to the Severity of Coronary Artery Disease and Its Prognostic Value
试验速览
- 阶段
- 不适用
- 入组人数
- 100
- 主要终点
- the severity of coronary artery disease and short term clinical outcomes
研究概览
简要总结
To assess the platelet indices in patients undergoing primary percutaneous coronary intervention and its relation to the severity of coronary artery disease and short term clinical outcomes
详细描述
Acute coronary syndromes (ACS) is a type of acute coronary artery disease (CAD), It is a highly prevalent group of emergency diseases, associated with high morbidity and mortality (1)
ACS include ST- elevation Myocardial Infarction (STEMI), non ST-Elevation Myocardial Infarction (NSTEMI) and Unstable Angina (UA) (2).
ACS characterized by plaque rupture and acute thrombosis formation in the coronary arteries (3)
platelet morphology and function have vital roles in the pathogenesis of many diseases related to coagulation, thrombosis, inflammation, and endothelial dysfunction (4)
Platelets play a crucial role in thrombotic episodes, its activation is acritical factor in the creation and evolution of atherothrombosis. (5)
研究设计
- 研究类型
- Observational
- 观察模型
- Other
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 75 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Adult patients (age ≥ 18 years) that presented with acute ST elevation myocardial infarction
排除标准
- •Cardiomyopathy,
- •Previous revascularization procedure
- •Any history of bleeding diathesis
结局指标
主要结局
the severity of coronary artery disease and short term clinical outcomes
时间窗: follow up patients 6 monthes
Platelet indices as mean Platelet Volume (MPV)in femtoliter , platelet distribution width (PDW) (FL)% and (PCT)% May be larger and could be a risk of Stratification in patients undergoing primary percutaneous coronary intervention
次要结局
未报告次要终点
研究者
Ishraq Hosny Abd El-Hameed Hassan
Critical Care Unit, Internal Medicine Department
Assiut University