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临床试验/NCT05090046
NCT05090046已完成不适用

Understanding Neurocognitive Impairment After Trauma Exposure

University of Otago1 个研究点 分布在 1 个国家目标入组 128 人开始时间: 2022年2月10日最近更新:
适应症

试验速览

阶段
不适用
状态
已完成
入组人数
128
试验地点
1
主要终点
Subjective cognitive function

研究概览

简要总结

Individuals living in Canterbury (New Zealand) have experienced significant stress related to the Canterbury earthquake sequence. Previous research conducted at the Department of Psychological Medicine (Christchurch, New Zealand) has shown significant cognitive difficulties in a group of Cantabrians exposed to high levels of earthquake trauma. A high proportion (30%) perceive themselves to have significant cognitive difficulties, even seven years post-earthquake. People who perceive that they have cognitive difficulties find this distressing and tend to function less well in work and parenting. Understanding pathways underlying cognitive difficulties in the population is vital for developing appropriate treatments and strategies to help with this.

This will be the first study to investigate rates of, and factors contributing to, perceived cognitive difficulties in a large population exposed to multiple stressors and is important for the population of Canterbury, and populations affected by natural and man-made disasters worldwide.

Four hundred and sixty people who were exposed to the Canterbury earthquake sequence will be recruited from the Christchurch Health and Development Study (CHDS). Psychological, cognitive, functional and biological factors will be compared between those with the greatest levels of perceived cognitive difficulty and those with the lowest levels of difficulty. This will determine what factors relate most strongly to perceived cognitive difficulties, which will in turn be used to develop treatments for this population.

研究设计

研究类型
Observational
观察模型
Cohort
时间视角
Cross Sectional

入排标准

年龄范围
44 Years 至 46 Years(Adult)
性别
All
接受健康志愿者

入选标准

  • Cohort member of the Christchurch Health and Development Study (born in 1977)
  • Exposed to the Canterbury earthquake sequence
  • In the highest or lowest quartile with regards to score on the Cognitive Failures Questionnaire

排除标准

  • lifetime diagnosed psychotic disorder
  • previous moderate to severe head injury (> 30 minutes loss of consciousness)
  • current pregnancy
  • intellectual disability (IQ < 80)
  • residing outside of Canterbury

结局指标

主要结局

Subjective cognitive function

时间窗: Past 6 months

Assessed with the Cognitive Failures Questionnaire Minimum score = 0, maximum score = 100, higher scores reflect worse subjective cognitive function

次要结局

  • Visuospatial learning and memory(Baseline)
  • Metabolic markers(Baseline)
  • Stressful life events(Past 5 years)
  • Global cognitive composite(Baseline)
  • Verbal learning and memory(Baseline)
  • Psychomotor speed(Baseline)
  • Working memory(Baseline)
  • Sustained attention(Baseline)
  • Facial emotion processing(Baseline)
  • Executive function(Baseline)
  • Rumination(Baseline)
  • Mental health diagnoses(Baseline)
  • Sex hormones(Baseline)
  • Metacognitive beliefs(Baseline)
  • Psychosocial functioning(Past 2 weeks)
  • COVID-19 impact(Past 3 years)
  • Post-traumatic growth(Past 12 years)
  • Inflammation(Baseline)

研究者

申办方类型
Other
责任方
Sponsor

研究点 (1)

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