Understanding Neurocognitive Impairment After Trauma Exposure
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 128
- 试验地点
- 1
- 主要终点
- Subjective cognitive function
研究概览
简要总结
Individuals living in Canterbury (New Zealand) have experienced significant stress related to the Canterbury earthquake sequence. Previous research conducted at the Department of Psychological Medicine (Christchurch, New Zealand) has shown significant cognitive difficulties in a group of Cantabrians exposed to high levels of earthquake trauma. A high proportion (30%) perceive themselves to have significant cognitive difficulties, even seven years post-earthquake. People who perceive that they have cognitive difficulties find this distressing and tend to function less well in work and parenting. Understanding pathways underlying cognitive difficulties in the population is vital for developing appropriate treatments and strategies to help with this.
This will be the first study to investigate rates of, and factors contributing to, perceived cognitive difficulties in a large population exposed to multiple stressors and is important for the population of Canterbury, and populations affected by natural and man-made disasters worldwide.
Four hundred and sixty people who were exposed to the Canterbury earthquake sequence will be recruited from the Christchurch Health and Development Study (CHDS). Psychological, cognitive, functional and biological factors will be compared between those with the greatest levels of perceived cognitive difficulty and those with the lowest levels of difficulty. This will determine what factors relate most strongly to perceived cognitive difficulties, which will in turn be used to develop treatments for this population.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 44 Years 至 46 Years(Adult)
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Cohort member of the Christchurch Health and Development Study (born in 1977)
- •Exposed to the Canterbury earthquake sequence
- •In the highest or lowest quartile with regards to score on the Cognitive Failures Questionnaire
排除标准
- •lifetime diagnosed psychotic disorder
- •previous moderate to severe head injury (> 30 minutes loss of consciousness)
- •current pregnancy
- •intellectual disability (IQ < 80)
- •residing outside of Canterbury
结局指标
主要结局
Subjective cognitive function
时间窗: Past 6 months
Assessed with the Cognitive Failures Questionnaire Minimum score = 0, maximum score = 100, higher scores reflect worse subjective cognitive function
次要结局
- Visuospatial learning and memory(Baseline)
- Metabolic markers(Baseline)
- Stressful life events(Past 5 years)
- Global cognitive composite(Baseline)
- Verbal learning and memory(Baseline)
- Psychomotor speed(Baseline)
- Working memory(Baseline)
- Sustained attention(Baseline)
- Facial emotion processing(Baseline)
- Executive function(Baseline)
- Rumination(Baseline)
- Mental health diagnoses(Baseline)
- Sex hormones(Baseline)
- Metacognitive beliefs(Baseline)
- Psychosocial functioning(Past 2 weeks)
- COVID-19 impact(Past 3 years)
- Post-traumatic growth(Past 12 years)
- Inflammation(Baseline)
