Protective effect of ulinastatin against colistin-induced acute kidney injury in patients with severe pneumonia

Yonsei University, Wonju Severance Christian Hospital0 个研究点目标入组 60 人开始时间: 待定最近更新: 2021年1月6日

试验速览

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•1. Adults over 20 years old
•2. Patients with septic shock due to pneumonia or who are treated in the intensive care unit (if admitted to the intensive care unit, they are considered as severe pneumonia regardless of the presence or absence of a ventilator or the severity of pneumonia)
•3. Infection with multidrug-resistant Acinetobacter baumannii (ABA) or Pseudomonas aeruginosa (PAE) susceptible only to colistin, confirmed in culture test of lower airway samples.
•? Definition of septic shock
•It is defined as septic shock if it satisfies all the criteria for ? sepsis and ? septic shock, or only meets the criteria for ? septic shock.
•? Definition of sepsis
•If two or more of the following four items are met;
•? Body temperature >38? or <36?
•? Heart rate >90/min
•? Respiration rate >20/min or PaCO2 <32mmHg
•? White blood cells >12,000/?or <4,000/?
•? Definition of septic shock
•Mean arterial pressure (MAP) <65mmHg
•[MAP = (systolic blood pressure + 2 x diastolic blood pressure)/3]
•? Definition of multidrug resistance
•Multi-drug resistance is defined when resistance to all drugs including imipenem, except for colistin, is shown.

•1. If ABA or PAE is confirmed in culture test, but regarded as simple colonization rather than the causative agent of pneumonia.
•2. Patients currently receiving any cancer treatment including lung cancer (if patients received cancer treatment but is cured, it does not fall under the exclusion criteria.)
•3. Serum creatinine (Cr) = 2.0 mg/dl

发起方

Yonsei University, Wonju Severance Christian Hospital