Examination of Metabolic Determinants of Behavior and Motivation in Obesity: Implication to the Development of New Strategies for Achieving Body Weight Health
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 40
- 试验地点
- 1
- 主要终点
- Correlation between metabolic measures and health-related behaviors in normal weight and overweight/obese perimenopausal women.
研究概览
简要总结
This study will be a cross-sectional study. The primary aim of this study is to compare the relationship between neurological function, metabolic measures and health-related behaviors between normal weight and overweight/obese perimenopausal women.
详细描述
To examine physiological and behavioral factors that may help determine health in perimenopausal middle age women. Neuroendocrine function will be measured by broad assessment of hypothalamic-pituitary-adrenal (HPA) activity. We will also assess metabolic profiles and behavioral and emotional function. We plan to determine correlations between these measures and nutritional state. Other measures may include insulin, glucose, leptin, IGF-1, triglycerides, free fatty acids, and ghrelin and eating attitudes and physical reactivity.
研究设计
- 研究类型
- Observational
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 42 Years 至 52 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •Body Mass index 18-39.9 kg/m2
- •Peri-menopausal status by self-report
排除标准
- •Plan to become pregnant
- •Breastfeeding in the last 6 months
- •Multiple sclerosis, amyotrophic lateral sclerosis, Parkinson's disease
- •Menopause confirmed
- •Unable to refrain from smoking for five hours (self-report)
- •Unable to refrain from consuming alcohol for two days (self-report)
- •Weight change > 10 lbs in the preceding 6 months
- •Chronic corticosteroid use
- •Oral corticosteroids used more than twice in the last 12 months
- •Hormonal contraceptives
- •Antipsychotic, anti-anxiety and anti-depressant medications
- •Beta adrenergic blockers
- •Sibutramine, orlistat, phentermine, phendimetrazine, topiramate, zonisamide
- •Immunosuppressants
- •Amphetamines and other stimulants
- •Severe food allergies or intolerances to foods
- •Insulin Dependent Diabetes Mellitus
结局指标
主要结局
Correlation between metabolic measures and health-related behaviors in normal weight and overweight/obese perimenopausal women.
时间窗: 3 months
次要结局
未报告次要终点