Evaluation of Laparoscopic Peritoneal Lavage for Perforated Diverticulitis: A National Registry - Based Study
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 52,863
- 主要终点
- Preferred operation for acute colonic diverticular disease
研究概览
简要总结
The goal of this observational study is to study the emergency surgical treatment of diverticular disease in Sweden outside clinical trials. The main questions it aims to answer are:
- Which is the preferred surgical method of acute diverticular disease in Sweden?
- Which are the short and long-term outcomes of the different surgical methods?
Researchers will compare the different methods to see if there is a surgical operation that is superior for the treatment of acute diverticulitis.
详细描述
A retrospective study of patients who were admitted to a Swedish hospital between 1st July 2014 and 31st December 2020 with an ICD-10 code for diverticular disease of the large intestine (K57.2- K57.9) will be included. Patients who underwent procedures relevant to diverticulitis will be identified and therefore will be included. Procedures will be grouped into two categories: Laparoscopic peritoneal lavage (Group I), and sigmoid resection with or without stoma (Group II).
The cohort will be studied from 1st January 1997 until the index date aiming to assess comorbidities, previous abdominal surgeries, and admissions for diverticular disease. A Charlson Comorbidity Index (CCI) system adjusted for Swedish ICD-10 version will be used to calculate a composite score to reflect comorbidity.
研究设计
- 研究类型
- Observational
- 观察模型
- Other
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •All patients aged 18 years or older who were admitted to a Swedish hospital between 1st July 2014 and 31st December 2020 with an ICD-10 code for diverticular disease of the large intestine (K57.2- K57.9).
- •Emergency admissions.
- •Patients who underwent procedures relevant to diverticulitis.
排除标准
- •Patients who were diagnosed with colorectal cancer before the index date.
- •Patients with synchronous operations that are supposed to be irrelevant to acute diverticulitis.
结局指标
主要结局
Preferred operation for acute colonic diverticular disease
时间窗: Up to 78 months
Laparoscopic peritoneal lavage or sigmoid resection
次要结局
- Crossover surgery(1 day)
- Reoperation(From date of inclusion until the date of the end of study or date of death from any cause, whichever came first, assessed up to 78 months)
- Postoperative length of hospital stay(From date of inclusion until the date of discharge, assessed up to 78 months)
- Overall survival(From date of inclusion until the date of the end of study or date of death from any cause, whichever came first, assessed up to 78 months)
- Thirty-day postoperative mortality(Up 30 days)
- Colorectal cancer diagnosis(From date of inclusion until the date of the end of study or date of death from any cause, whichever came first, assessed up to 78 months)
研究者
Christos Kollatos
MD
Uppsala University Hospital