The Relationship Between Sarcopenia and Orthostatic Hypotension
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 100
- 试验地点
- 1
- 主要终点
- Change in blood pressure
研究概览
简要总结
Elderly patients generally have a tendency for having sarcopenia which refers to muscle loss that may be related to many factors. These patients also have a tendency to falls and injuries. Whether elderly sarcopenic patients have abrupt blood pressure drops upon standing remains unknown. Therefore, in this study, we sought to determine the incidence of orthostatic hypotension in sarcopenic elderly patients and compare it with elderly patients with no sarcopenia.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 75 Years 至 —（Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Patients 75 years or older
排除标准
- •Pace-maker
- •End stage renal insufficiency
- •End stage malignancy
- •Dehydration
- •Severe anemia ( Hgb < 8 gr/dl)
- •Acute infection
- •Marked edema
- •Neurodegenerative disease
结局指标
主要结局
Change in blood pressure
时间窗: 0-3 minutes
All blood pressure measurements will be performed in the morning after an eight-hour fasting. After 5-minute rest, the first blood pressure measurement will be taken when the patients are supine. Later, three more consecutive measurements will be recorded when the patients stand up each being one-minute apart. All measurements will be performed using a fully automated sphygmomanometer that is attached with the correctly sized cuff matching to the patients' upper arm circumference. OH is defined as a decrease in systolic blood pressure of 20 mm Hg or a decrease in diastolic blood pressure of 10 mm Hg within 3 minutes of standing. The accompanying symptoms such as dizziness, unable to maintain balance, blurred vision will also be recorded.
次要结局
未报告次要终点
研究者
Kudret Keskin
Principle Investigator
Sisli Hamidiye Etfal Training and Research Hospital