ABT-335 (Choline Fenofibrate)Reverse Cholesterol Transport (RCT) Study
试验速览
- 阶段
- 1 期
- 状态
- 已完成
- 入组人数
- 25
- 试验地点
- 1
- 主要终点
- Mean Change in Calculated Low Density Lipoprotein Cholesterol
研究概览
简要总结
The objectives of the study are:
- To evaluate the effect of ABT-335 (choline fenofibrate) on several parameters of RCT (reverse cholesterol transport) in men and post-menopausal women diagnosed with dyslipidemia (i.e., low high-density lipoprotein [HDL] cholesterol levels and elevated triglyceride [TG] concentrations).
- To evaluate longitudinal changes in several parameters of RCT in subjects with low HDL.
- To obtain pilot data for power calculations for subsequent comparative study.
详细描述
This trial assesses the effects of ABT-335 on RCT as measured by cholesterol efflux or rate of appearance of cholesterol (Ra in mg/kg/hr), cholesterol excretion (%/day), RCT efflux (mg/kg/day) and de novo cholesterol synthesis (%) during a baseline period (7 days) and during a treatment period (94 days).
The goal of using RCT to reverse atherosclerosis is to increase the rate of cholesterol export or "efflux" from the tissues and plaques. An increase in this cholesterol efflux rate should shrink arterial plaques by decreasing their static accumulation of cholesterol. While some currently marketed drugs have a positive impact on RCT by increasing the rate of cholesterol excretion from the body, no drug has yet been approved to increase the rate of cholesterol efflux from the tissues
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 21 Years 至 75 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Male, non-smoker, 21 - 75 years of age inclusive.
- •Female, non-smoker, 40 - 75 years of age inclusive.
- •Post-menopausal women, as defined by lack of menses for at least 2 years and age > 55, OR history of documented bilateral surgical oophorectomy, confirmed with an elevated follicle-stimulating hormone (FSH) at screening.
- •HDL concentration (≤ 50 mg/dl women, ≤ 40mg/dl men)
- •TG concentration 150-500 mg/dl, inclusive
- •Ability to give informed consent
排除标准
- •Subject has history of diabetes mellitus, active hepatitis, gall bladder disease, gastric bypass surgery, or clinically significant abnormalities on screening (prestudy) physical examination or laboratory tests.
- •Screening laboratory tests with hematocrit <30%, aspartate aminotransferase (AST)/alanine aminotransferase (ALT) > 2X upper limit of normal, abnormal thyroid-stimulating hormone (TSH), fasting glucose ≥126 mg/dl.
- •Renal impairment with creatinine clearance < 80 ml/min.
- •Treatment within the last 6 months with drugs known to alter lipid metabolism including beta blockers, thiazide diuretics, bile acid resins, ezetimibe, fibrates, niacin, and fish oils (see Appendix 1). Washout of fibrates is not permitted.
- •Treatment with drugs known to interact with ABT-335, e.g., warfarin (see Appendix 1).
- •Treatment with HMG CoA reductase inhibitors (statins) within the past 4 weeks (see Appendix 1).
- •History of allergy to egg or soy products.
- •History of coronary heart disease (CHD), stroke or revascularization procedure in the six months prior to Visit
- •Current or recent history (past 12 months) of drug abuse or alcohol abuse. Alcohol abuse will be defined as >14 drinks per week (1 drink = 12 oz beer, 5 oz wine, or 1.5 oz hard liquor).
- •Participation in another clinical trial or exposure to any investigational agent within 30 days before visit
- •Individual has a condition the Principal Investigator believes would interfere with his/her ability to provide informed consent, comply with study instructions, or which might confound the interpretation of the study results or put the subject at undue risk.
研究组 & 干预措施
Abt-335
ABT-335 (choline fenofibrate)
干预措施: choline fenofibrate (Drug)
结局指标
主要结局
Mean Change in Calculated Low Density Lipoprotein Cholesterol
时间窗: baseline to 12 weeks
Mean change in calculated LDL, baseline (average Day 0, 1 10) to end-of-treatment (12 weeks treatment,average Day 95)
Mean Change in Plasma Triglycerides
时间窗: baseline to 12 weeks
Change in plasma triglyceride, baseline (average Day 0, 1 10) to end-of-treatment (12 weeks treatment,Day 95)
Mean Change in High Density Lipoprotein Cholesterol
时间窗: Baseline to 12 weeks
Mean change in plasma high density plasma lipoprotein cholesterol (HDL-C)baseline (average Day 0, 1 10) to end-of-treatment (12 weeks treatment,Day 95)
Total Cholesterol
时间窗: 12 weeks
Mean Change in total cholesterol from baseline to End-of-treatment (Day 95)
次要结局
- Plasma Cholesterol Efflux(12 weeks)
- Change in Plasma Cholesterol Ester Fractional Catabolic Rate (FCR)(Baseline to 12 weeks)
- Percent Change in de Novo Cholesterol Synthesis(Baseline to 12 weeks)
- Change in Neutral Sterol Excretion(baseline to 12 weeks)
- Change in Bile Acid Excretion(Baseline to 12 weeks)
- Neutral Sterol Endogenous Excretion(12 weeks)
- Endogenous Bile Acid Excretion(12 weeks)