Assessment in Healthy Volunteers of the Analgesic Effect Monitored by the NOL Index of a Hypnotherapy Session Versus a Calm Waking State During Standardized Thermal Harmful Stimulation. The HYPTHENOL Study

Study desing: Monocentric, prospective randomized test in "crossover" (each subject being its own witness), comparing the analgesic effect of a hypnotherapy session versus a calm standby state.

Population studied: Healthy volunteers, adults Sample size: 12 subjects will be included in total, each one being subjected to the two sessions with different conditions (hypnosis versus calm watch state) subjects will be evaluated and classified by the hypnotisability score of the Harvard group scale of hypnotic susceptibility form A (HGSHS: A) translated into French by Hernan A and J Becchio

Participants will be classified into 4 groups :

i)Highly hypnotizable group (10-12), ii) Moderately hypnotizable group (7-9) iii)Slightly hypnotizable group (3-6) iv)Little hypnotizable group (0-2) The first two groups (score of 7 and more) will be included in the experimental study.Evaluation will be carried out according to 2 states over 2 different days, with a minimum interval between the two sessions of 48 hours.State of calm watch with thermal stimulation = control condition (session 1 or 2 depending on randomization).State of hypnotic trance with thermal stimulation and associated with hypnotic analgesic suggestions = experimental condition (session 1 or 2 depending on randomization).Thermal stimulation is performed using a Thermo Q-sense thermal probe (Medoc Advanced Medical Systems, Israel). The probe will first be calibrated before contact with the subject. Then, the probe will be placed on the palm side of the left hand for all subjects and during the two sessions (calm and hypnosis).This probe has already been used by our team for other research work and is completely safe, causing no skin damage to the subject. The Department of Anesthesiology and Pain Medicine owns this device. The temperature varies between 30 ° to 50 ° C in about 30 seconds, and stops under three conditions: when the subject clicks on a controller, at his requests, or when this temperature reaches 50 ° C.The NOL index: the NOL will be recorded continuously through the PMD200TM monitor, available at HMR in current clinical practice of anesthesia. Registration will begin at the start of sessions and procedures. PMD200TM also records heart rate values automatically.Sedline (EEG monitor peranesthesia, Masimo, CA, USA) will also be connected to the subject to assess the spectrogram of EEG waves (electroencephalography) with or without hypnosis. This monitor is non-invasive and gives its parameters using an electrode that sticks to the subject's forehead. These monitors are used in common clinical anesthesia practice and are available and used at HMR.The data will be electronically exported at the end of the experiment in a completely anonymous manner and kept in confidential, anonymous and protected electronic files of the study for a period of 7 years.

A pre-hypnosis consultation with the subjects will take place just before the session in order to harvest a place of safety and , assess its major communication channel, collect useful information for the realization of the "analgesic glove", establish a signal with him to rule on the state of trance and answer their questions.Even if the protocol is standard in its design, the protocol remains specific to each participant and adapted to the place of "safe place" and / or to the characteristics of the protective glove or "analgesic glove" that participant has chosen.