NCT06970223进行中（未招募）1 期
Phase 1, Open-Label, Randomised Crossover Study Assessing the Tolerability and Acceptability of Long Acting Cabotegravir Intramuscular and Lenacapavir Subcutaneous Injections Over Time in Healthy Adults Without HIV
适应症
干预措施
相关药物
试验速览
- 阶段
- 1 期
- 状态
- 进行中（未招募）
- 入组人数
- 65
- 试验地点
- 1
- 主要终点
- Percentage of participants reporting very acceptable or totally acceptable local reactions
研究概览
简要总结
This study will evaluate the tolerability and acceptability of injection site reactions (ISRs) of two long-acting (LA) injectables. Additional characteristics of the ISRs will be investigated and described as well as safety outcomes.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Prevention
- 盲法
- None
盲法说明
Open-label
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Participants are eligible to be included in the study only if all the following criteria apply:
- •At the time of obtaining informed consent, 18 years of age.
- •Body weight 50 kg and BMI within the range 18 to 32 kg/m2 (inclusive).
- •Participants who are overtly healthy as determined by medical evaluation by a responsible and experienced physician, including medical history, physical examination, laboratory tests and cardiac monitoring.
- •A participant with a significant clinical abnormality or laboratory parameter(s) which is/are not specifically listed in the inclusion or exclusion criteria, outside the reference range for the population being studied may be included if the investigator determines and documents that the finding is unlikely to introduce additional risk factors and will not interfere with the study procedures. A single repeat of a procedure or lab parameter is allowed to determine eligibility.
- •Male or female at birth (transgender individuals are not excluded but LEN may interfere with gender affirming hormones including increasing thrombotic risk. This should be discussed with Medical Monitor).
- •All participants are expected to use barrier methods for HIV/STI prevention and should be counselled accordingly at all visits.
- •Contraceptive use by men and women should be consistent with local regulations regarding the methods of contraception for those participating in clinical studies.
- •Participants assigned female at birth are eligible to participate if they are not pregnant or breast/chest-feeding, and at least 1 of the following conditions applies:
- •Is not a person of childbearing potential (POCBP) OR
- •Is a POCBP and using a contraceptive method that is highly effective, with a failure rate of <1%. The investigator should evaluate the effectiveness of the contraceptive method in relationship to the first dose of study intervention.
- •A POCBP must have a negative highly sensitive pregnancy test (urine and/or serum as required) within the 21 days before the dose of study intervention.
- •Must be capable of giving written informed consent, which includes compliance with the requirements and restrictions listed in the informed consent form (ICF) and in this protocol.
排除标准
- •Participants are excluded from the study if any of the following criteria apply:
- •History or presence of cardiovascular, respiratory, hepatic, renal, gastrointestinal, endocrine, hematologic, or neurological disorders capable of significantly altering the absorption, metabolism, or elimination of drugs; constituting a risk when taking the study intervention or interfering with the interpretation of data. The investigator may contact the ViiV healthcare (VH) medical monitor to discuss the inclusion of participants who have a history of specific conditions that are not expected to interfere with their participation in the study.
- •Suspected or known active, serious infection(s).
- •Abnormal blood pressure as determined by the investigator.
- •History of any malignancy within the past 5 years. Exceptions are squamous and basal cell carcinomas of the skin and carcinoma in situ of the cervix, or malignancy which is considered cured with minimal risk of recurrence. Participants under evaluation for possible malignancy are not eligible.
- •Breast cancer within the past 10 years
- •Current or chronic history of liver disease or known hepatic or biliary abnormalities (with the exception of Gilbert's syndrome or asymptomatic gallstones).
- •The participant has an underlying skin disease or disorder (i.e., infection, inflammation, dermatitis, eczema, drug rash, drug allergy, psoriasis, food allergy, urticaria) that would interfere with assessment of injection sites.
- •Current or anticipated need for chronic anti-coagulation.
- •Participants considered to have insufficient musculature to allow safe intramuscular (e.g., gluteus medius, vastus lateralis) or sufficient subcutaneous thickness to allow subcutaneous administration in the opinion of the investigator.
- •Any Positive Treponeme Specific Serologic testing (positive T. Pallidum antibody immunoassay + Rapid plasma reagin [RPR] or positive T. Pallidum antibody immunoassay + Treponema pallidum particle agglutination [TPPA]) is exclusionary.
- •Presence of HBsAg, or positive hepatitis C antibody test result at Screening or within 3 months prior to first dose of study treatment.
- •Have a history of osteoporosis or bone fragility fractures.
- •Participants who, in the investigator's judgment, poses a significant suicidality risk. Participant's history of suicidal behaviour and/or suicidal ideation should be considered when evaluating for suicide risk.
- •Any preexisting physical or mental condition which, in the opinion of the Investigator or the Medical Monitor, may interfere with the participant's ability to comply with the dosing schedule and/or protocol evaluations or which may compromise the safety of the participant.
- •Participants receiving any protocol-prohibited medication and who are unwilling or unable to switch to an alternate medication.
- •Treatment with any of the following agents within 60 days of screening: radiation therapy, cytotoxic chemotherapeutic agents, any systemic immune suppressant.
- •Past or intended use of over-the-counter or prescription medication including herbal medications within 7 days prior to dosing.
- •Use of glucocorticoids (through any route).
- •Exposure to more than 4 new investigational products within 12 months prior to the first dosing day.
- •Current enrolment or past participation in another investigational study in which an investigational intervention (e.g., drug, human blood product, monoclonal antibody, vaccine, invasive device) was administered within 1 month, 5 half-lives or twice the duration of the biological effect of the test agent prior to screening (whichever is longer).
- •Any acute laboratory abnormality at Screening, which, in the opinion of the investigator, would preclude the participant's participation in the study of an investigational compound.
- •Any verified Grade 4 laboratory abnormality, with the exception of Grade 4 triglycerides or lipid abnormalities. A single repeat test is allowed during the screening period to verify a result.
- •ALT greater than or equal to (>=) 1.5x ULN. A single repeat test is allowed within a single Screening period to determine eligibility.
- •Total bilirubin >=1.5x ULN (isolated total bilirubin greater than [>] 1.5xULN is acceptable if total bilirubin is fractionated and direct bilirubin less than [<] 35%). A single repeat test is allowed within a single screening period to determine eligibility.
- •Creatinine clearance (eGFR) of <60 mL/min/1.73 m2 via CKD-EPI method.
- •Positive HIV antibody/antigen test (HIV-1, HIV-2) at screening or enrolment. Participants will be advised regarding safer sex. In the event a participant acquires HIV during the study they will be required to withdraw from the study and will be referred urgently to an HIV treatment center for further management.
- •Clinically significant cardiovascular disease, as defined by history/evidence of congestive heart failure, symptomatic arrhythmia, angina/ischemia, coronary artery bypass grafting surgery or percutaneous transluminal coronary angioplasty or any clinically significant cardiac disease.
- •Grade 3 or Grade 4 proteinuria or glycosuria at screening that is unexplained or not clinically manageable.
- •Participant is unlikely to adhere to the study procedures, keep appointments, is planning to relocate during the study, or remain on study through to its conclusion.
- •Alcohol or substance use that, in the opinion of the study investigator and medical monitor, would interfere with the conduct of the study (e.g., provided by self-report, or found upon medical history and examination or in available medical records).
- •Participant has an implant/enhancement (including fillers) at the area of proposed injection; or tattoo or other dermatological condition overlying the area for IM or SC injection (e.g., gluteus medius, vastus lateralis or anterior abdominal wall) or any other area which may significantly interfere with interpretation of injection site reactions.
研究组 & 干预措施
CAB LA/LEN LA Group
Experimental
Participants receive the CAB LA injection at Day 1 followed by the LEN LA injections at Day 15.
干预措施: Cabotegravir long-acting (Drug)
LEN LA/CAB LA Group
Experimental
Participants receive the LEN LA injections at Day 1 followed by the CAB LA injection at Day 15.
干预措施: Cabotegravir long-acting (Drug)
CAB LA/LEN LA Group
Experimental
Participants receive the CAB LA injection at Day 1 followed by the LEN LA injections at Day 15.
干预措施: Lenacapavir long-acting (Drug)
LEN LA/CAB LA Group
Experimental
Participants receive the LEN LA injections at Day 1 followed by the CAB LA injection at Day 15.
干预措施: Lenacapavir long-acting (Drug)
结局指标
主要结局
Percentage of participants reporting very acceptable or totally acceptable local reactions
时间窗: 7 days after each injection (injections administered on Day 1 and Day 15)
The analysis is performed using the 21-item perception of injection (PIN) questionnaire which includes 21 items grouped into 4 multi-item domains: 'Acceptance of ISR' scale score (2 items); 'Bother from ISR' scale score (6 items); 'Leg movement' scale score (4 items); 'Sleep' scale score (4 items); and 5 standalone items: pain during injection; anxiety before injection; anxiety after injection; willingness to be injected in the future; and overall satisfaction with mode of administration. Participant responses are scored on a 5-point Likert scale, where 1 represents the least favorable perception of injection and 5 the most favorable, with domain scores calculated as the mean of all items in that domain. "Acceptance of ISR" is reported in this outcome measure for 2 scores: "very acceptable ISR: and "totally acceptable ISR".
次要结局
- Number of participants with change in laboratory parameters over time(Up to 6 months post any injection compared to Baseline (Day 1))
- Percentage of participants reporting very acceptable or totally acceptable local reactions at days 43 and 190(At Day 43 (28 days after second injection) and Day 190 (26 weeks after second injection))
- Mean injection site reaction scores, over time, post-injection, at days 8 and 22(At Day 8 and Day 22 (7 days after each injection visit))
- Median injection site reaction scores, over time, post-injection, at days 8 and 22(At Day 8 and Day 22 (7 days after each injection visit))
- Mean injection site reaction scores, over time, post-injection, at days 43 and 190(At Day 43 (28 days after second injection) and Day 190 (26 weeks after second injection))
- Percentage of participants with ISRs overall and by severity(Up to 6 months post any injection)
- Maximum change in toxicity grade from baseline in laboratory values(Up to 6 months post any injection compared to Baseline (Day 1))
- Median injection site reaction scores, over time, post-injection, at days 43 and 190(At Day 43 (28 days after second injection) and Day 190 (26 weeks after second injection))
- Change in the intensity of post-injection site pain assessed over time(At days 1, 2, 5 and 8 for the first injection and days 15, 16, 19, and 22 for the second injection)
- Percentage of participants with specific ISRs of interest(Up to 6 months post any injection)
- Mean duration of ISRs(Up to 6 months post any injection)
- Median duration of ISRs(Up to 6 months post any injection)
- Percentage of participants with adverse events (AEs) overall and by severity(Up to 6 months post a single dose of CAB LA and LEN LA sequentially administered)
- Number of participants with laboratory abnormalities(Up to 6 months post any injection)
研究者
研究点 (1)
Loading locations...
相似试验
终止
1 期
A Study of APL-1501 Extended Release Capsules Compared to APL-1202 Immediate Release Tablets in Healthy VolunteersHealthy VolunteersNCT06435039Syneos Health12
已完成
3 期
A Trial Evaluating Two Subcutaneous Injection Techniques and Intramuscular Administration of Degarelix in Patients With Prostate CancerProstate CancerNCT02526784Ferring Pharmaceuticals120
已完成
1 期
Study to Assess Safety & Tolerability of AZD2281 in Combination With Bevacizumab in Patients With Advanced Solid TumoursNeoplasm MetastasisNCT00710268AstraZeneca18
已完成
1 期
Safety Study of VM202 to Treat Amyotrophic Lateral SclerosisAmyotrophic Lateral SclerosisNCT02039401Helixmith Co., Ltd.18
已完成
1 期
A Phase I Study to Evaluate the Safety, Reactogenicity, and Humoral Immune Responses to an Inactivated H5N1 Influenza VaccineAvian InfluenzaInfluenza A(H5N1)Bird FluNCT01675284Medigen Biotechnology Corporation36