Evaluation of the Effect of Propolis Versus Calcium Hydroxide, Intracanal Medicaments on Post-Operative Pain in Patients With Necrotic Pulp (A Randomized Clinical Trial)
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 46
- 主要终点
- post-operative pain
研究概览
简要总结
Propolis is a resinous product of honeybees. Propolis is said to be effective against resistant microorganisms inside the root canal compared to the gold standard medication known as calcium hydroxide. The clinical trial tests the effect of propolis versus calcium hydroxide on pain in patients with necrotic teeth.
详细描述
Propolis is an immunomodulatory, antioxidant, flavonoid-rich resinous product of honeybees. Propolis was reported as less cytotoxic and more effective against resistant microorganisms than calcium hydroxide as well as biocompatible to the periradicular tissues than existing intracanal medicaments. The aim of this single-blinded randomized clinical trial was to evaluate the effect of propolis versus calcium hydroxide, intracanal medicaments, on post-operative pain in patients with necrotic single canal teeth. Methods: Forty-six participants with an age range of 20-40 years old, diagnosed as having necrotic pulp in their single-rooted, single canal teeth were included in this study, with 23 participants in each group. Treatment was done in two visits and intracanal medicament was applied for one week in between. Participants were instructed to rate their pain score by a numerical rating scale after 24, 48, 72 hours and at 7 days.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Diagnostic
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 20 Years 至 40 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •• Asymptomatic patients with age range 20 - 40 years
- •Necrotic, single canal maxillary and mandibular teeth with periapical infection presented as radiolucency or widening in the periodontal membrane space.
- •Medically - free of any systemic disease
- •Teeth with complete root formation
排除标准
- •• Pregnant or lactating females
- •Teeth with vital pulps, internal or external resorption or anatomic abnormalities
- •Teeth with cracks, curvatures, root caries and calcified canals
- •Double or triple-rooted teeth
- •Patients with facial swelling, acute pulpal or periapical lesion
- •Teeth that are not indicated for endodontic treatment: Bad oral hygiene, mobile or recessed
- •Previously endodontically-treated teeth
研究组 & 干预措施
Propolis
intervention intracanal medicament
干预措施: propolis (Dietary Supplement)
Calcium Hudroxide
Gold standard intracanal medicament
干预措施: Calcium Hydroxide (Drug)
结局指标
主要结局
post-operative pain
时间窗: one week. line of 10 points
Categorical data on numerical rating scale
次要结局
未报告次要终点
研究者
Serene Mohamed Hisham Sirry
Principle Investigator
Cairo University