Neural and Mechanical Baroreflex Sensitivity and Cerebral Blood Flow
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 22
- 试验地点
- 1
- 主要终点
- Baroreflex sensitivity
研究概览
简要总结
This project aims to evaluate the physiological effects of Midodrine administration during orthostatic challenge in those with high level spinal cord injury. Midodrine has been shown to improve orthostatic symptoms in those with spinal cord injury but the physiological mechanisms influenced have not been identified. The investigators will examine key physiological components influencing orthostatic tolerance. The investigators will do this, by measuring the baroreflex, and brain blood flow autoregulation (the ability to maintain brain blood flow) before during and after the sit-up test. Two sit-up tests will occur; one before Midodrine administration, and one after administration of a 10mg dose of Midodrine.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 49 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •To be included in the study, participants must have sustained a traumatic spinal cord injury within the ages of 18-49 years.
- •Also, participants must have an injury level above the 6th thoracic vertebrae and be a non-smoker for a minimum of one year.
排除标准
- •Any participants with a history of cardiovascular disease, pulmonary disease or diabetes mellitus will not be eligible.
- •Also, participants will not be eligible to take part in study if they experiences acute distress, or are taking medications known to influence cardiovascular function.
- •Patient will be not eligible for the study if he/she has known adverse reaction to Midodrine.
结局指标
主要结局
Baroreflex sensitivity
时间窗: Immediately after drug administration (30 mins)
次要结局
- Cerebral autoregulation(Thirty minutes after administration)
研究者
Andrei Krassioukov
Principal Investigator
University of British Columbia