Hyperoncotic albumin to improve diuresis in critically ill patients: a pilot randomized controlled trial

McMaster University Medical Centre (Canada)0 个研究点目标入组 50 人开始时间: 2013年9月20日最近更新: 2019年5月5日

适应症

试验速览

•Intensive care unit patients, medical or surgical, of at least 18 years of age who meet the following criteria:
•1. Hemodynamically stable for at least 24 hours
•1.1. Absence of persistent (>1h) hypotension (systolic blood pressure < 90 mmHg) and tachycardia (heart rate >110)
•1.2. Not currently on vasopressors other than low dose dopamine (less than 10 mcg/kg/min)
•1.3. Less than 2L crystalloid or colloid boluses or 2 units PRBCs, maintenance fluids excluded
•2. Hypoproteinemia
•2.1. Serum albumin < 30 mg/L, or total protein < 60 mg/L
•3. Clinical decision to diurese at least 3L net fluid balance within the next 72 hours
•4. For any reason, including: peripheral edema, congestive heart failure on chest x-ray, elevated CVP in the absence of right heart valvular pathology or pulmonary hypertension, elevated wedge pressure

•1. Known pregnancy
•2. Patient or surrogate unable or unwilling to consent to blood product administration, including albumin
•3. History of adverse reactions or allergy to either albumin or furosemide
•4. Acute kidney injury (RIFLE criteria ?F? or greater - tripling of creatinine or creatinine >355 µmol/l (with a rise of >44) or average urine output below 0.3 ml/kg/hr for 24 hours) without any improvement in the past 24 hours, or otherwise expected to necessitate dialysis within 48 hours in the opinion of the treating physician
•5. Chronic kidney injury requiring dialysis
•6. Clinically documented cirrhosis
•7. Clinically documented nephrotic syndrome
•8. Serum sodium greater than 150 meq/L, or serum potassium less than 2.5 meq/L that cannot be treated prior to administration of study treatment
•9. Inability to measure urine output and fluid balance
•10. Receipt of hyperoncotic albumin within the preceding 24 hours
•11. Previous enrollment in this RCT, or any other research studies which may interfere with this study
•12. Estimated survival or ICU stay less than 72 hours.

发起方

McMaster University Medical Centre (Canada)