NCT00002043已完成不适用
Dapsone 100 Mg Versus 50 as Primary Prophylaxis for Pneumocystis Carinii Pneumonia (PCP) in Patients With AIDS-Related Complex (ARC)
Jacobus Pharmaceutical2 个研究点 分布在 1 个国家开始时间: 2001年8月31日最近更新:
适应症
相关药物
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 试验地点
- 2
研究概览
简要总结
To determine which of 2 doses of dapsone is effective prophylaxis for Pneumocystis carinii pneumonia (PCP) in patients with oral thrush or hairy leukoplakia and less than 400 CD4 lymphocytes per mm3. To determine whether the long-term toxicities associated with daily dapsone in this population are tolerable.
研究设计
- 研究类型
- Interventional
- 主要目的
- Treatment
入排标准
- 年龄范围
- 12 Years 至 —（Child, Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •The patient must have HIV positive antibody test and presence of oral thrush or hairy leukoplakia.
- •Patient must be willing and able to sign informed consent.
排除标准
- •Co-existing Condition:
- •Patients with the following are excluded:
- •Prior Pneumocystis carinii pneumonia (PCP) or AIDS-defining condition.
- •Prophylaxis for PCP in preceding 3 months.
- •Absence of detectable glucose-6-phosphate dehydrogenase (G6PD) activity.
- •Prior type I hypersensitivity (anaphylaxis, urticaria, angioedema) or exfoliative dermatitis during treatment with dapsone.
- •History of poor compliance.
- •Concurrent Medication:
- •Zidovudine (AZT).
- •Patients with the following are excluded:
- •Prior Pneumocystis carinii pneumonia (PCP) or AIDS-defining condition.
- •Prophylaxis for PCP in preceding 3 months.
- •Absence of detectable glucose-6-phosphate dehydrogenase (G6PD) activity.
- •Concurrent or prior therapy with zidovudine (AZT).
- •Prior type I hypersensitivity (anaphylaxis, urticaria, angioedema) or exfoliative dermatitis during treatment with dapsone.
- •History of poor compliance.
- •Prior Medication:
- •Zidovudine (AZT).
研究者
研究点 (2)
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