临床试验/NCT02105064

NCT02105064已完成不适用

Repetitive Transcranial Magnetic Stimulation (rTMS) as an add-on Treatment for Resistant Obsessive-compulsive Symptoms in Patients With Schizophrenia

Hospital de Clinicas de Porto Alegre1 个研究点分布在 1 个国家目标入组 12 人开始时间: 2011年7月1日最近更新: 2016年3月8日

适应症

干预措施

试验速览

阶段: 不适用
状态: 已完成
发起方: Hospital de Clinicas de Porto Alegre
入组人数: 12
试验地点: 1
主要终点: Change of Obsessive Compulsive symptoms (using Yale-Brown Obsessive Compulsive Scale - Y-BOCS)

研究概览研究设计入排标准研究组 & 干预措施结局指标研究者研究点记录与标识符相似试验

研究概览

简要总结

This is a study to evaluate the efficacy of rTMS for relief of obsessive-compulsive symptoms in patients with schizophrenia.

研究设计

研究类型: Interventional
分配方式: Randomized
干预模型: Parallel
主要目的: Treatment
盲法: Triple (Participant, Care Provider, Outcomes Assessor)

入排标准

年龄范围: 18 Years 至 60 Years（Adult）
性别: All
接受健康志愿者: 否

入选标准

•Diagnosis of Schizophrenia (DSM-IV-TR)
•YBOCS ≥ 16

排除标准

•Mental Retardation
•Substance abuse
•Any contraindication to rTMS

研究组 & 干预措施

Active rTMS

Active Comparator

rTMS over Supplementary Motor Area, 1hz, no pauses, 20 minutes per sessions. Total: 20 sessions.

干预措施: Active rTMS (Device)

Sham

Sham Comparator

Sham stimulation, 20 minutes per session, total 20 sessions

干预措施: SHAM rTMS (Device)

结局指标

主要结局

Change of Obsessive Compulsive symptoms (using Yale-Brown Obsessive Compulsive Scale - Y-BOCS)

时间窗: Baseline, after 20 rTMS sessions (an expected average of 4 weeks), and 4 weeks after end of treatment

次要结局

Change of Psychotic Symptoms (using Brief Psychiatric Rating Scale - BPRS)(Baseline, after 20 rTMS sessions (an expected average of 4 weeks), and 4 weeks after end of treatment)
Change of Brain-Derived Neurotrophic Factor (BDNF)(Baseline, after 20 rTMS sessions (an expected average of 4 weeks), and 4 weeks after end of treatment)

研究者

发起方

Hospital de Clinicas de Porto Alegre

申办方类型

Other

责任方

Sponsor

研究点 (1)

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