PheWAS of a Polygenic Predictor of Thyroid Function
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 37,154
- 试验地点
- 1
- 主要终点
- thyroid disorders associated with a polygenic predictor of thyroid stimulating hormone levels
研究概览
简要总结
Performing a phenome-wide association study (PheWAS) identifying clinical diagnoses associated with a polygenic predictor of Thyroid stimulating hormone (TSH) levels identified by a previously published genome-wide association study (GWAS). PheWAS will be applied in an electronic-health-record (EHR) cohort including North American (n: 37,154) and European participants using 1,318 phenotypes.
详细描述
Applying a genetic predictor of thyroid stimulating hormone levels to an electronic-health-record cohort to verify associations with thyroid disorders as positive controls, and identify new associations .
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 28 Years 至 100 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Being part of the eMERGE Phase I & II Network
- •Being part of the BioVU resource
- •Falling within 4 standard deviations for each of the first 2 principal components based on common single nucleotide variants (SNVs) for the subset of subjects self-identified as "White, non-Hispanic"
排除标准
- •born after 1990
结局指标
主要结局
thyroid disorders associated with a polygenic predictor of thyroid stimulating hormone levels
时间窗: population inclued in the eMERGE Phase I & II Network or BioVU resource until 1 july 2018
All relevants statisticals associations between a defined polygenic predictor of TSH and thyroids disorders
次要结局
- Clinical diagnoses associated with a polygenic predictor of TSH levels(population inclued in the eMERGE Phase I & II Network or BioVU resource until 1 july 2018)
研究者
Joe Elie Salem
Assistant director, clinical investigation center Paris Est
Groupe Hospitalier Pitie-Salpetriere