A randomised controlled trial aimed at enhancing immunity to influenza in elderly individuals through reversal of immune senescence mediated by herpes virus infection

niversity of Birmingham (UK)0 个研究点目标入组 700 人开始时间: 2011年8月17日最近更新: 2018年6月11日

适应症

试验速览

暂无简介。

•1. Aged 65 years or above (30% 65-74 yrs old, 70% aged over 75 yrs)
•2. Cytomegalovirus (CMV) seropositive
•3. CMV-specific CD8+ and CD4+ T cell response over 0.5% of T cell pool at randomisation
•4. Human leuckocyte antigen (HLA) type of HLA-A1, A2, B7 or B8
•5. Predicted epidermal growth factor receptor (eGFR) > 50ml/min
•6. Liver function tests (LFT) in normal range
•Target Gender: Male & Female ; Lower Age Limit 65 years

•1. On the following medication : Steroids, ciclosporin, mycophenolate, probenecid, tacrolimus, theophylline
•2. Significant chronic illness as assessed by clinical team
•3. History of cardiovascular event in the last 6 months
•4. General practitoner (GP) considers inappropriate to take part
•5. Unable to provide written consent

发起方

niversity of Birmingham (UK)