Acute Effects of Supplemental Oxygen on Memory in Healthy Older Adults: a Double-Blind Within-Subject Crossover Study
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- Inogen Inc.
- 入组人数
- 40
- 试验地点
- 2
- 主要终点
- 2 back Memory test performance
研究概览
简要总结
Forty healthy adults (i.e., not recruited with respect to any particular diagnosis) are each alternately provided with supplemental oxygen and air via nasal cannula at about 6 Liters per Minute (LPM), while completing memory tests.
详细描述
Prior studies have reported that supplemental oxygen can confer acute benefits to cognition. Here, the investigators seek to replicate/extend such findings by assessing whether such benefits can be seen using an Inogen oxygen concentrator with subjects with an average age around 65 years old. The investigators include a standard measure of cognition previously reported to be sensitive to supplemental oxygen (2-back test) and a novel, in-development adaptation of a memory test for medical-related content (Medical icons spatial test).
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- Double (Participant, Outcomes Assessor)
入排标准
- 年龄范围
- 22 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Subjects are intended to represent "healthy adults." Patients will include a mix of self-reported gender and ethnic/racial identification.
- •Provision of signed and dated informed consent form
- •Stated willingness to comply with all study procedures and availability for the duration of the study
- •Adult (aged 22+)
排除标准
- •Patients who self-report diagnosis of respiratory-related conditions will be excluded.
- •Subjects with a known polyvinyl chloride (PVC) allergy will be excluded, due to potential use of a standard, PVC-based cannula in the study.
结局指标
主要结局
2 back Memory test performance
时间窗: At baseline and 5 mins post-intervention exposure
\# correct on 2-back test
Memory test performance
时间窗: At baseline and 5 mins post-intervention exposure
New Medical Icons Spatial Test
次要结局
未报告次要终点