NCT05789433招募中不适用
Effects of Aerobic Exercise on Skeletal Muscle Remodeling in Colorectal Cancer
适应症
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 70
- 试验地点
- 2
- 主要终点
- Whole-Body Intermuscular Adipose Tissue
研究概览
简要总结
The goal of this clinical trial is to quantify the effects of aerobic exercise training compared to attention control on intermuscular adipose tissue in colorectal cancer survivors.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Supportive Care
- 盲法
- Double (Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age ≥18 years
- •Histologically confirmed stage I, II, or III colon or rectal cancer
- •Completed surgical resection with curative intent
- •Completed other cancer-directed treatments
- •Engage in <150 minutes per week of moderate- to vigorous-intensity structured endurance exercise
- •No planned major surgery during the study period
- •Readiness to exercise, as determined by a modified version of the Physical Activity Readiness Questionnaire
- •Ability to provide written informed consent
- •Provide written approval by a qualified healthcare professional
- •Willing to be randomized
排除标准
- •Evidence of metastatic or recurrent colorectal cancer
- •Concurrently actively treated other (non-colorectal) cancer
- •Scheduled to receive other postoperative cancer-directed treatment(s)
- •Currently pregnant, breastfeeding, or planning to become pregnant within the next 24 weeks
- •Currently participating in another study with competing outcomes
- •Contraindications to magnetic resonance imaging
- •Any dietary condition or restriction that would limit tolerance of a mixed meal challenge
- •Any other cardiovascular, pulmonary, orthopedic, neurologic, psychiatric, or other condition that, in the investigator's opinion, would preclude participation or successful compliance with the protocol
- •Any other situation that, in the opinion of the investigator, would negatively impact subject safety or successful compliance with the protocol
结局指标
主要结局
Whole-Body Intermuscular Adipose Tissue
时间窗: up to Week 12
Mean (kg) whole-body intermuscular adipose tissue quantified using magnetic resonance imaging.
次要结局
未报告次要终点
研究者
Justin Brown
Director, Exercise & Cancer Biology Research Program
AdventHealth Translational Research Institute
研究点 (2)
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