Exploratory Analysis of DOTATATE PET for Meningioma Radiation Planning
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 36
- 试验地点
- 2
- 主要终点
- Target radiation volume
研究概览
简要总结
68Ga-DOTATATE-based radionuclides are a novel modality in the diagnosis and treatment of central nervous system meningioma. DOTATATE is a ligand for the SSTR (somatostatin receptor), which is expressed in meningioma but not in normal brain or bone. It is also more effective than MRI in delineating tumor, which is the current imaging standard for assessing meningioma. For radiation planning, it can help to reduce the risk of geometrical miss, identify area that require dose-escalation, and reduce dose to normal tissue. The purpose of the study is to compare the radiation therapy (RT) contouring and planning for meningioma with and without the use of 68Ga-DOTATATE-PET
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age ≥ 18 years old
- •Able and willing to comply with the study procedures
- •Intact meningioma requiring definitive radiation
- •Post-operative meningioma requiring adjuvant radiation
- •No prior radiation therapy or medical therapy directed at the tumour
排除标准
- •Breastfeeding or pregnancy
- •Claustrophobia or inability to lie still in a supine position
- •Unwillingness or inability to provide informed consent
结局指标
主要结局
Target radiation volume
时间窗: 2 years
The volume of gross total volume (GTV), clinical target volume (CTV), planned target volume (PTV) contours, and volume of dose exposure to normal brain tissue using standard imaging and DOTATE-PET scan
次要结局
- Local control(2 years)
- Progression-free survival(2 years)
- Perceived usefulness by radiation oncologist(2 years)
- Adverse event(2 years)
- Rate of DOTATATE-scan completion(2 years)
- Extent of post-operative disease volume compared to MRI(2 years)
- Overall survival(2 years)