Reducing Particulate Matter-associated Cardiovascular Health Effects for Seniors
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 40
- 主要终点
- brachial blood pressure
研究概览
简要总结
The objective of this study is to investigate the effectiveness of air filtration at reducing personal-level exposures to fine particulate matter (PM2.5) and mitigating related cardiovascular (CV) health effects among older adults in a residential facility in a representative US urban location.
We enrolled 40 nonsmoking older adults into a randomized double-blind crossover intervention study with daily CV health outcomes and PM2.5 exposure measurements. The study was conducted in a low-income senior living apartment building in downtown Detroit, Michigan.
Participants were exposed to three 3-day scenarios separated by one-week washout periods: unfiltered ambient air (control), low-efficiency (LE) "HEPA-type", and high-efficiency (HE) "true-HEPA" filtered air using air filtration systems in the bedroom and main living space of each residence.
The primary outcome was brachial blood pressure (BP). Secondary outcomes included noninvasive aortic hemodynamics and pulse wave velocity and heart rate variability. PM2.5 exposures were measured in the participants' residences as well as by personal-level monitoring.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- Double (Participant, Outcomes Assessor)
入排标准
- 年龄范围
- 50 Years 至 85 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •50 to 85 years old
- •non-smoking healthy adults
排除标准
- •smoke or anyone in your residence smokes.
- •had a cardiovascular event within the past 6 months (such as myocardial infarction (heart attack), angina, cardiac or carotid surgery or stent, diagnosed peripheral arterial disease, aortic aneurysms, treated heart failure, any treated arrhythmia including atrial fibrillation)
- •have renal disease requiring dialysis.
- •have had medication changes in the past 6 weeks.
- •use supplementary oxygen.
结局指标
主要结局
brachial blood pressure
时间窗: at the same time between 8-10 AM on 3 consecutive days starting 24 hours after filter system placement
Brachial blood pressure was measured using a BPTru device.
次要结局
- heart rate variability(at the same time between 8-10 AM on 3 consecutive days starting 24 hours after filter system placement)
- microvasculature tone(at the same time between 8-10 AM on 3 consecutive days starting 24 hours after filter system placement)
- noninvasive aortic hemodynamics(at the same time between 8-10 AM on 3 consecutive days starting 24 hours after filter system placement)
- Pulse wave velocity(at the same time between 8-10 AM on 3 consecutive days starting 24 hours after filter system placement)
研究者
Masako Morishita
Associate Professor
Michigan State University