Efficacy of balance re-education, neural mobilisation, resistive and activities of daily living training on chemotherapy induced peripheral neuropathy in cancer survivors: Two arm randomised controlled trial
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 28
- 试验地点
- 1
- 主要终点
- Modified total neuropathy score A 6 -item tool that combines patient report of subjective sensory and motor symptoms, deep tendon reflexes, manual muscle testing of distal muscles, pin sensibility, and quantitative vibration thresholds.
研究概览
简要总结
There is rising prevalence of cancer, many individuals are living with side effects of its treatment, as chemotherapy is the mainline treatment. Few studies have been done to investigate potentially beneficial effects of specific exercise to counteract chemotherapy induced peripheral neuropathy symptoms in cancer survivors. The rehabilitative potential of exercise has been so far less investigated and the results are divergent. The majority of studies are done on non natives of India focusing on one or two protocols only at one time. So there is need to investigate the effect of balance Re-education, neural mobilisation, Resistive and activities of daily living training in chemotherapy induced peripheral neuropathy on cancer survivors.
In this study following procedure will be followed:
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The purpose and benefit of the research will be explained to the cancersurvivors having Chemotherapy induced peripheral neuropathy
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Consent for participation in research will be taken from the patients
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Meeting the inclusion andexclusion criteria
4.Baseline assessment willbe performed
Patient divided intotwo groups
| EXPERIMENTAL GROUP |
CONTROL GROUP
|N = 14
N = 14
|Will be given intervention exercises, With proper guidance, counseling and precautions.
Education regarding chemotherapy induced peripheral neuropathy its consequences and role of exercises.
研究设计
- 研究类型
- Interventional
- 盲法
- Investigator Blinded
入排标准
- 年龄范围
- 18.00 Year(s) 至 60.00 Year(s)（—）
- 性别
- All
入选标准
- •Age 18-60 years had primary diagnosis of cancer -Given chemotherapeutic regimen for atleast 1 cycle -Both Male and female -All types of cancer -Had a karnofsky performance status ≥ 70 -Should be able to walk 3 meters -Have at least 1 neuropathy symptom according to CIPN assessment tool (CIPNAT).
排除标准
- •Hereditary peripheral neuropathy .{ e.g., Charcot-marie-tooth disease} -If they had other chronic neuropathic disease likes Diabetic Neuropathy, Multiple Sclerosis, Neuritis etc.
- •Orthopaedic problem that affect balance (e.g. ACL reconstruction) -Vestibular disorder and visual acuity problem -Chronic inflammatory demyelinating polyneuropathy -Concomitant disease like diabetes, renal insufficiencies -Prior history of alcohol abuse -Lower limb amputee -Use of walking Aid -Treatment with antiepileptic drugs, antidepressants and major analgesics.
结局指标
主要结局
Modified total neuropathy score A 6 -item tool that combines patient report of subjective sensory and motor symptoms, deep tendon reflexes, manual muscle testing of distal muscles, pin sensibility, and quantitative vibration thresholds.
时间窗: will be assessed at baseline and after 3 weeks
• 0 -24 points, higher score indicates worse neuropathy.
时间窗: will be assessed at baseline and after 3 weeks
次要结局
- functional independence measure(The test/Questionaire will be assessed at the baseline and at the end of 3 weeks. (Pre and Post))
- UNIPEDAL STANCE TEST(•Patients were asked to stand barefoot on the limb of their choice, with the other limb raised so that the raised foot was near but not touching the ankle of their stance limb.)
- timed up and go test(The test/Questionaire will be assessed at the baseline and at the end of 3 weeks. (Pre and Post))