Develop and Implement Methods for Diagnostic and Treatment of Hormonal Disorders in Patients With Chronic Kidney Disease
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 400
- 试验地点
- 1
- 主要终点
- Hormanal changes in patients with CKD
研究概览
简要总结
Methods of diagnostic and treatment of hormonal disorders in patients with chronic kidney disease (CKD) will be developed and implemented in real clinical practice. As a result of the project, new scientific data will be obtained on the relationship of hyperprolactinemia and impaired functioning of the pituitary-gonadal axis, changes in functioning of the renin-angiotensin-aldosterone system will be revealed, and the characteristics of the thyroid and parathyroid status in patients with CKD will be determined, including receiving renal replacement therapy (RRT) and after kidney transplantation, which will improve the efficiency of diagnosis and treatment of hormonal disorders in the early stages of the disease, reduce the direct financial costs of the diagnostic and treatment process primarily due to the optimization of hormonal studies and treatment of the revealed disorders, as well as will prevent the progression of CKD and the severity of the condition of this category of patients due to the development of hormonal dysfunctions.
详细描述
- Assessment of prevalence, clinical manifestations and pathological significance in a cohort of patients with CKD:
- hyperprolactinemia, hormonal disorders of a pituitary -gonad axis ;
- disorders of renin-angiotensin-aldosterone system;
- pathology of the thyroid and parathyroid glands.
- Analysis of CKD impact on the development of structural changes in the thyroid gland and parathyroid glands according to the results of ultrasound examination.
- Assessment of relationship of hormonal dysfunctions in patients with CKD and adipocytokines, markers of renal impairment.
- To study the effect of renal replacement therapy on thyroid hormones clearance .
- Investigate hormonal status in patients with CKD after kidney transplantation.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •patients at CKD 1-5, including renal replacement therapy and renal transplantation
排除标准
- •patients with impaired thyroid function before the onset of CKD;
- •pregnant women;
- •patients with acute diseases;
- •patients in the acute phase of comorbid chronic diseases;
- •patients in the acute period of myocardial infarction, after acute cerebrovascular accident;
- •patients with mental illness;
- •patients undergoing treatment for various cancer types.
结局指标
主要结局
Hormanal changes in patients with CKD
时间窗: Baseline
Deviations from reference interval ranges of prolactin, thyroid hormones, PTH and vitamin D and its associations with renal impairment markers
次要结局
未报告次要终点
研究者
Tatiana Mokhort
Professor, MD, Head of Endocrinology Department
Belarusian State Medical University