europrotective Effects of Exercise in People with Progressive Multiple Sclerosis: a phase II trial.

Amsterdam UMC, location VUmc0 个研究点目标入组 60 人开始时间: 待定最近更新: 2024年6月11日

适应症

试验速览

暂无简介。

•PMS diagnosis defined as: ‘definite diagnosis of MS according to the 2017 McDonald Criteria with gradual progression of neurological impairments according to the Lublin criteria 2013.’
•EDSS Scale 3.5 – 6
•Able to participate in the exercise programs, i.e. no contra-indications for training according to the guidelines of the American college of Sports Medicine.
•oNo history of heart problems
•oNo symptoms that might indicate heart problems
•oNo other major health issues
•Age between 18 and 60 years old
•Able to understand therapists instructions
•Fulfilling the safety criteria for magnetic resonance (MR) assessment
•oNo metal inside the body
•oNot claustrophobic
•oNo pregnancy

•Diagnosed with PPMS
•Relapse within 3 months of baseline visit
•Severe comorbidity (Cumulative Illness Rating Scale (CIRS) = 3 on 1 or more organ systems).
•Initiation of Fampridine within 6 months of baseline visit.
•Depression, Hospital Anxiety and Depression Scale (HADS) score, depression subscale =11 (i.e. indicative of clinical anxiety disorder or clinical depression)
•Other neurological- and/or musculoskeletal disorders
•Already participating in a (guided) high intensity exercise training
•Participating in another intervention study
•Pregnancy, given birth previous 6 months, or active pregnancy wish.

发起方

Amsterdam UMC, location VUmc