Targeted Physical and Cognitive Activity in a VR Environment - COVID-19 Protocol
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 14
- 试验地点
- 1
- 主要终点
- Mnemonic Similarity Task for visual memory performance - discrimination index
研究概览
简要总结
The overarching goal of this pilot clinical trial is to use a novel virtual reality (VR)-based intervention that simultaneously engages physical and cognitive activity aimed at improving brain and cognitive outcomes in older adults. Physical activity is a promising lifestyle intervention for mitigating cognitive decline or delaying onset of dementia. However, to fully leverage beneficial brain effects of physical activity, training the brain to learn and engage in a cognitively stimulating environment may be the key to enhanced brain and cognitive outcomes.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Other
- 盲法
- None
入排标准
- 年龄范围
- 50 Years 至 85 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •50-85 Years Old
- •Able to Walk Without Assistance
- •Fluent in English
- •No Ferromagnetic Metal in Body
- •Able to Participate in Moderate Aerobic Physical Activity
排除标准
- •Severe Brain Injury/ Head Trauma
- •Pacemakers or Metal Implants
- •Claustrophobia
- •Contradictions to Magnetic Resonance Imaging (MRI)/ Positron Emission Tomography (PET) Brain Scans
- •Opposition to Blood Draws
研究组 & 干预措施
Combined, simultaneous physical and cognitive activity
The combined physical and cognitive activity VR arm will participate in our customized spatial navigation program that increases difficulty and length per trial over time. As described in the Game Design section, each session will consist of 5 trials. The first trial will be a long-delay free recall condition from the previous day's path. The next 4 trials will consist of learning, cued recall, and free recall. This VR-based spatial navigation program has been tested in our feasibility trial for safety and tolerability in older adults.
干预措施: Physical and Cognitive Activity (Behavioral)
结局指标
主要结局
Mnemonic Similarity Task for visual memory performance - discrimination index
时间窗: 12 weeks
With the study's primary focus on hippocampal function, we will use the Mnemonic Separation Task (MST), a hippocampus-dependent discrimination test of similar objects, as our primary cognitive outcome.
Magnetic Resonance Image (MRI) brain scan of hippocampal volume (cubic mm)
时间窗: 12 weeks
The hippocampus has been shown to be a selectively vulnerable region in Alzheimer's Disease (AD), and several studies, including our own, identified a dysfunctional brain signal in the hippocampus in Mild Cognitive Impairment (MCI) patients. We propose to examine the effects of exercise on remediating this hyperactive signal exhibited in MCI patients.
次要结局
未报告次要终点
研究者
Judy Pa
Associate Professor of Neurology
University of Southern California