Left Bundle Branch Pacing Versus Right Ventricular Pacing in Patients With Atrioventricular Block: an Observational Cohort Study
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 1,000
- 试验地点
- 1
- 主要终点
- composed of all-cause mortality, lead failure and heart failure hospitalization (HFH) during the follow-ups
研究概览
简要总结
Although emerging evidence demonstrated that left bundle branch pacing (LBBP) is a promising alternative for patients with either a bradycardia or a heart failure pacing indication. However, a direct comparison of the safety, efficacy and LV systolic synchrony between LBBP and RVP regimens was rare. In this study, the investigators aim to conduct a comparison of the safety and effectiveness performance between these two pacing methods for patients with atrioventricular block (AVB). The investigators focused on AVB patients undergoing permanent pacemaker implantations from the 1st of January 2018 to the 18th of November 2021 at West China Hospital.
详细描述
Right ventricular pacing (RVP) is the standard treatment for patients with continuous ventricular pacing needs. However, clinical studies have shown that RVP can cause electrical and mechanical dyssynchrony of the left ventricle and increase the risks of cardiac insufficiency, atrial fibrillation (AF) and death. Although emerging evidence demonstrated that left bundle branch pacing (LBBP) is a promising alternative for patients with either a bradycardia or a heart failure pacing indication. However, a direct comparison of the safety, efficacy and LV systolic synchrony between LBBP and RVP regimens was rare. In this study, the investigators aim to conduct a comparison of the safety and effectiveness performance between these two pacing methods for patients with atrioventricular block (AVB). The investigators focused on AVB patients undergoing permanent pacemaker implantations from the 1st of January 2018 to the 18th of November 2021 at West China Hospital.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •included consecutively high-grade AVB patients undergoing permanent pacemaker implantations from the 1 s t of January 2018 to the 18 thof November 2021 at West China Hospital
排除标准
- •patients with pacemaker replacements were excluded.
结局指标
主要结局
composed of all-cause mortality, lead failure and heart failure hospitalization (HFH) during the follow-ups
时间窗: through study completion, an average of 2.45 year
composed of all-cause mortality, lead failure and heart failure hospitalization (HFH) during the follow-ups
Lead failure
时间窗: through study completion, an average of 2.45 year
reintervention for increased pacing thresholds, lead dislocation or ventricular perforation after the initial implantation procedure
HFH
时间窗: through study completion, an average of 2.45 year
HFH was defined as the admission to hospital for \>24 hours with worsening symptoms and signs of heart failure and requiring one or more intravenous diuretics or intravenous inotropic medications
次要结局
- peri-procedure complication(through study completion, an average of 2.45 year)
- cardiac death(through study completion, an average of 2.45 year)
- recurrent unexplained syncope(through study completion, an average of 2.45 year)
研究者
Zhongxiu Chen
Dr, cardiology department, principal investigator
West China Hospital