Simultaneous Prospective Kidney Transplant Assessment in Combined Liver Kidney
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 15
- 试验地点
- 1
- 主要终点
- perform a nuclear medicine scan prior to SLK transplant
研究概览
简要总结
The purpose of the study is to determine how much a persons kidney function recovers after receiving a simultaneous liver kidney transplant. The investigators will be contacting patients with kidney dysfunction with estimated GFR between 25 and 40 (not on dialysis treatment) who are listed to receive a simultaneous liver kidney (SLK) transplant to look at this function recovery. The investigators hope to develop a criteria based on GFR measurement, kidney function calculations from native kidneys vs transplanted kidney and compare the contributions, and correlate with estimated GFR on basic metabolic panel (BMP: a blood test) to predict higher chances of recovery of native kidney function.
详细描述
Study design
Study will be a pilot longitudinal prospective study. SLK transplant listed patients will be recruited from the outpatient Liver Kidney Transplant Clinic at Medical Diagnostic Clinic (MDC) as well as inpatients admitted to IU University Hospital. Listing status for SLK transplant will be confirmed and patients will be scheduled for a Mag3 nuclear medicine scan at IU University Department of Nuclear medicine. For study purposes, this scan will be done pre and post-transplant to compare the results.
Methods:
Inclusion/Exclusion criteria:
Inclusion:
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •> 18 years old
- •Listed for Liver Transplant for ESLD and Kidney Transplant (not on dialysis at time of transplant surgery)
- •Candidates with two native kidneys.
- •Willing to participate and sign informed consent form.
排除标准
- •Unstable patients (e.g. in the ICU or those who are on Continuous Renal Replacement Therapy (CRRT) who cannot complete the nuclear medicine scan or those with AKI on Hemodialysis
- •Prior history of any solid organ transplant.
- •Those who are currently pregnant or breast feeding.
- •Patients who have Autosomal Dominant polycystic kidney disease
研究组 & 干预措施
People with ESLD and eGFR between >=25 and <=40ml/min
- > 18 years old
- Listed for Liver Transplant for ESLD and Kidney Transplant (not on dialysis)
- Candidates with two native kidneys.
- Willing to participate and sign informed consent
干预措施: Nuclear Medicine Scan (Radiation)
结局指标
主要结局
perform a nuclear medicine scan prior to SLK transplant
时间窗: up to 100 weeks
To determine split kidney function with a Mag3 (Mercaptoacetyltriglycine 3) nuclear medicine renal scan as part of the study procedures.
次要结局
- To measure and correlate Clinical, laboratory and Radiographic data at the time of SLK transplant will be reviewed(up to 100 weeks)
研究者
Muhammad Yahya Jan
Assistant Professor of Clinical Medicine
Indiana University