Vitamin D Supplementation and Exercise for Improving Physical Function in Overweight and Obese Older Adults With Low Vitamin D Levels

Prof. Peter Ebeling0 个研究点目标入组 50 人开始时间: 2016年5月2日最近更新: 2022年5月2日

适应症

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•Community-dwelling; age 50-80 years; BMI 25-40 (overweight or obese); low vitamin D status (serum 25-hydroxyvitamin D [25OHD] less than or equal 49.9nmol/L); willing, and has GP approval, to complete a 12-week exercise intervention, willing to be randomised to either vitamin D or placebo.

•Self-reported inability to unable to walk 400 metres non-stop unassisted (ie. without use of walking aids); non-English speaking; vitamin D supplementation greater than or equal to 1000 International Units/day; 4 weeks self-reported participation in a supervised exercise program targeted at weight loss or strength gains in the past six months; planning to be away from home for more than 2 weeks during the training phase; women who are pregnant or are trying to become pregnant; and self-reported diagnosis of: Progressive neurological disorders including Parkinson’s Disease and multiple sclerosis; schizophrenia or bipolar disorder; severe knee or hip osteoarthritis (awaiting a joint replacement) that would interfere with ability to complete functional tests; lung disease requiring regular use of supplemental oxygen; renal disease requiring dialysis, any other disorder of such severity that life expectancy is less than 12 months; and stroke, hip or knee replacement, spinal surgery, myocardial infarction or major heart surgery in the past 6 months. Also, use of medications contraindicated for vitamin D supplementation including: thiazide diuretics, cholestyramine, colestipol, corticosteroids, mineral oil, orlistat, phenytoin, barbiturates, digitalis glycosides, and antacids (magnesium).

发起方

Prof. Peter Ebeling