Penyagolosa Trail Saludable Women
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 50
- 试验地点
- 1
- 主要终点
- Change in the biochemical parameters related to kidney injury, dehydration, inflammation, and cardiac damage
研究概览
简要总结
This study has as main objective to asses different genetic, biochemical and physiological biomarkers affecting performance and health status in ultraendurance runners according to individual's sex.
详细描述
Ultraendurance races has been shown to impact on several health-related biomarkers, and therefore they may have detrimental effects on runners' health. In this study, we aim to analyze the impact of running a 107,6 km mountain race in ultraendurance runners splitting our sample by individual's sex.
To do this, baseline measurements of the runners have been collected through stress tests and biochemical analyses of blood and urine samples. Indeed, a saliva sample was collected to isolated a genomic DNA sample of each runner.
During the race anthropometrical, ventilatory and strength data was collected in three different moments and after crossing the finish line. Indeed, after completed the ultraendurance mountain race, blood and urine samples were taken at the finish line, as well as 24h and 48h post-race.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Healthy adults (>18 years old)
- •Volunteers should be finish at least one ultraendurance mountain race (>60km).
排除标准
- •Having heart disease
- •Having kidney disease
- •Taking a medication on an ongoing basis
结局指标
主要结局
Change in the biochemical parameters related to kidney injury, dehydration, inflammation, and cardiac damage
时间窗: 12 hours before the race, 15 minutes after the race, 24 hours after the race and 48 hours after the race
Blood concentration of estradiol, testosterone, progesterone, creatinine, troponin, C-reactive protein, hemoglobin, sodium, potassium, chlorine, iron, and ferritin. Concentration of all these parameters is expressed in mass per volume (i.e. nanograms per milliliter)
Change in the power level
时间窗: 12 hours before the race, 15 minutes after the race
Squat Jump (high of the jump measured in centimeters)
Change in the Ventilatory Flow
时间窗: 60 minutes before the race, in three moments during the race (after running 33km, 65km and 94 km), and 15 minutes after the race
Ventilatory Flow measurement (liters per minute)
Analysis of tne changes in the Physical activity data
时间窗: From 9 hours before starting the race to 48 hours after crossing the finish line.
Physical activity measured by wearing accelerometer devices. Physical activity defined as sedentary, light, moderate, vigorous, very vigorous and extremely vigorous. The aim to wear accelerometers devices is to monitor individuals.
Change in the lung function
时间窗: 12 hours before the race, and 15 minutes after the race
Pulmonary function test by spirometry. The parameters measured are vital capacity (VC), forced vital capacity (FVC), maximal mid-expiratory flow (MEF) and total lung capacity. Outcome data of all these parameters are expressed in liters.
Change in the biochemical parameters related to immunological response
时间窗: 12 hours before the race, 15 minutes after the race, 24 hours after the race and 48 hours after the race
Blood concentration of erythrocytes, hematocrit, leukocytes, neutrophils, lymphocytes, monocytes, eosinophils, basophils, and platelet volume. The concentration of each cell type is expressed in number of cells per volume (cells per liter)
Change in the biochemical parameters related to muscle damage
时间窗: 12 hours before the race, 15 minutes after the race, 24 hours after the race and 48 hours after the race
Blood concentration of lactate dehydrogenase and creatine kinase. The enzyme concentration is expressed in units per volume (enzyme units per milliliter)
Change in the Strength level
时间窗: 12 hours before the race, in three moments during the race (after running 33km, 65km and 94 km), and 15 minutes after the race
Hand grip (pressure in kilograms)
Change in the lung function related to time
时间窗: 12 hours before the race, and 15 minutes after the race
Pulmonary function test by spirometry. The parameters measured are forced expiratory volume in 1 second (FEV1) and in 6 seconds (FEV6) and peak expiratory flow (PEF). Outcome data of all these parameters are expressed in liters per second.
Change in the biochemical parameters related to dehydration and kidney injury
时间窗: 60 minutes before the race and 15 minutes after the race
Urine test to measure the concentration of sodium and creatinine, as well as urine density
Analysis of the presence or absence of genetic markers related to endurance performance and ability to muscle damage recovery
时间窗: 12 hours before the race
Analysis of different polymorphisms in genomic DNA samples, which were isolated from the saliva sample of each participant.
Telomere length, genetic marker related to biological aging
时间窗: 12 hours before the race
Analysis of the telomere length in genomic DNA samples, which were isolated from saliva samples of each participant
次要结局
- Self-reported questionnaire about training habits(One month before the race day)
- Self-reported questionnaire about menstrual cycle (only for females)(One month before the race day)
- Assesment of physical condition by cardiopulmonary test(One month before the race day)
- Analysis of body composition (proportion of body fat, fat-free mass and water) per body areas (trunk, arms and legs)(12 hours before the race, and 15 minutes after the race,)
- Evaluation of effort subjective perception(60 minutes before the race, in three moments during the race (after running 33km, 65km and 94 km), and 15 minutes after the race)
- Heart rate(Through race completion (the time that a runner is performing the 107 kilometers of the race, an average of 25 hours))
- Self-reported questionnaire about social and health status(One month before the race day)
- Evaluation of muscle damage subjective perception per body areas(12 hours before the race, 15 minutes after the race, and 48 hours after the race)
- Change in the body mass(60 minutes before the race, in three moments during the race (after running 33km, 65km and 94 km), and 15 minutes after the race,)