NCT01796288Unknown2 期
The Value of Radiotherapy in the Oligometastatic Non-squamous Non-small Cell Lung Cancer With Clinical Benefits From Erlotinib as Second-line Treatment: a Randomized Controlled Phase II Clinical Trial
Wu Jieping Medical Foundation1 个研究点 分布在 1 个国家目标入组 200 人开始时间: 2012年10月最近更新:
适应症
干预措施
相关药物
试验速览
- 阶段
- 2 期
- 发起方
- 入组人数
- 200
- 试验地点
- 1
- 主要终点
- progession-free survival
研究概览
简要总结
This was a multi-center randomized controlled Phase II clinical trial. Patients with oligometastatic stage IV (number of distant metastases ≤ 5) non-squamous non-small cell lung cancer treated with second-line erlotinib150mg daily for 3 months with clinical benefits (free-from progression) were randomized (stratified according to smoking status and different research centers) to the radiotherapy group (n = 100) and the non-radiotherapy group (n = 100). Radiotherapy group (experimental group) patients started simultaneously radiotherapy for all gross tumors soon after randomization; non-radiotherapy group (control group) received no radiotherapy for all gross tumors. Erlotinib was continuously used until to disease progression or unbearable adverse effect, and the subsequently further salvage therapies were determined by the investigators. The primary endpoint was PFS.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Has signed informed consent;
- •Male or female aged 18 years or older;
- •Histologically or cytologically identified non-squamous non-small cell lung cancer;
- •PS score 0-2;
- •Stage IV patients with distant metastasis (according to the latest AJCC/UICC lung cancer staging, upper neck lymph nodes belonging to distant metastases; ipsilateral/contralateral mediastinal lymph nodes, supraclavicular and lower neck lymph nodes belonging to local regional areas and are not included in distant metastases), who occurred disease progression after receiving a course of systemic chemotherapy, or who hadn't complete the planned course of the first-line chemotherapy but they were intolerance or refused to continue treatment;
- •Received second-line erlotinib treatment;
- •The patients who taking erlotinib for 3 months then the efficacy evaluation found clinical benefits (CR+PR+SD);
- •Metastatic NSCLC with distant metastases number ≤ 5 (for metastases in the same organ, the number counted as the separate metastatic focus) and the longest diameter of each metastatic foci on CT should > 1cm, but brain (including the parenchyma and meninges) metastasis, malignant pleural/pericardial effusion, or abdominal effusion were not allowed;
- •Have never received local treatment, including surgery, radiation therapy, and radiofrequency ablation for primary and distant metastases;
- •Patients must received systemic PET-CT examination before treatment with erlotinib, to more accurately identify the status of patients with distant metastases;
- •The diagnosis of bone and liver metastases:
- •On the basis of clinical symptoms, an imaging support was necessary for the clinical diagnosis of bone metastases; if the clinical symptoms were absent, two imaging supports of bone metastases were necessary for the clinical diagnosis of bone metastasis; adjacent bone metastases (such as the two adjacent vertebral metastases) was considered to be a single metastasis.
- •MRI or enhanced CT confirmations were needed for liver metastases diagnosis;
- •Have never received other targeted drug treatments for EGFR inhibition;
- •If metastases in a same organ ≤ 4 and the amount of metastatic focus ≤ 5, it should be determined by the radiation therapists in the research group to judge if the patients can tolerate all positive focus (including primary and metastatic focus) receiving radiotherapy, the radiotherapy dose should be selected by treating physician according to the patients' conditions from several regimens including conventional split curative doses or palliative doses, and hypofractionated radiotherapy (for details please refer to the radiation therapy section);
- •Organ function levels must meet the following requirements:
- •Bone marrow: absolute neutrophil count (ANC) ≥ 1.0 × 109/L, platelets ≥ 80 × 109/L, hemoglobin ≥ 9 g/L;
- •Liver: serum bilirubin ≤ 1.5 times of the upper limit of normal, alanine aminotransferase (ALT) and aspartate aminotransferase (AST) ≤ 2.5 times of the upper limit of normal (if liver metastases existing, ALT, AST ≤ 5 times of the upper limit of normal were allowed) ;
- •Kidney: serum creatinine ≤ 2 times of the upper limit of normal or creatinine clearance ≥ 45mL/min;
- •For female patients: must after natural menopause, surgical menopause, or used any medical allowed contraceptive method during treatment and within 3 months after treatment completion; serum or urine pregnancy test must be negative; mustn't be in lactation. For male patients: surgical sterilization, or took contraceptive measures during treatment and within 3 months after treatment completion.
排除标准
- •The pathological type was squamous cell carcinoma, or mixed with small cell components in non-small cell lung cancer;
- •With brain metastasis regardless of parenchymal or meningeal metastasis;
- •Malignant pleural effusion, pericardial effusion or peritoneal effusion;
- •The longest diameter of metastatic focus on CT were <1cm, or the amount of metastatic focus > 5;
- •Metastases appeared within a same organ simultaneously;
- •The efficacy evaluation after erlotinib treatment for 3 months showed PD (progression of disease);
- •Local treatment had been used for the primary and distant metastatic focus;
- •Radiation therapists thought that the patient couldn't tolerate/receive radiotherapy for all the focus;
- •Has previously suffered from interstitial lung disease, drug-induced interstitial lung disease, or any active interstitial lung disease with clinical evidences;
- •Chest CT found idiopathic pulmonary fibrosis;
- •Patients with multiple pulmonary bullae, chronic lung disease, or acute lung infection;
- •With any chronic toxicity induced by previous anti-cancer treatment, it was undimunished and higher than CTCAE level 2;
- •Diagnosed or accompanied by any other malignant disease (except basal cell carcinoma or cervical carcinoma in situ) over the past five years;
- •According to the judgments of the investigators, there was any serious or uncontrolled systemic disease (e.g. heart, liver, or kidney disease) or active infection;
- •Combined use with phenytoin, carbamazepine, rifampicin, phenobarbital, or St. John's wort;
- •Naïve patients who have never received chemotherapy;
- •With previously clear history of neurological or psychiatric disorder, such as dementia;
- •Pregnancy or lactating patients;
- •Patients receiving other anti-tumor medicine not for this study.
研究组 & 干预措施
Erlotinib & simultaneous radiotherapy
Experimental
patients started simultaneously radiotherapy for all gross tumors
干预措施: simultaneous radiotherapy (Radiation)
Erlotinib & simultaneous radiotherapy
Experimental
patients started simultaneously radiotherapy for all gross tumors
干预措施: Erlotinib (Drug)
Erlotinib & no radiotherapy
Other
patients received no radiotherapy for all gross tumors
干预措施: Erlotinib (Drug)
结局指标
主要结局
progession-free survival
时间窗: 3.5 year
次要结局
- overall survival(5 year)
研究者
FU XIAO LONG
Fudan University Shanghai Cancer Center
Wu Jieping Medical Foundation
研究点 (1)
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