Exploring the Impact of Exercise-derived Extracellular Vesicle in Blood and Physical Fitness Data in Overweight/Obesity Individuals on Lymphangiogenesis
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 20
- 试验地点
- 2
- 主要终点
- Blood component assessment
研究概览
简要总结
This project aims to study the effect of exercise in the obesity/overweight on the changes of physical fitness and blood components. This will provide novel knowledge for medical staffs, researchers, or companies developing alternative strategies for treating obesity/overweight, including drug development and health promotion project to delay or prevent the onset of the disease.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 25 Years 至 45 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Male or female individuals aged between 25-45 years
- •Thai nationality
- •Ability to walk or perform daily activities independently, without the use of an assistive device
- •Body mass index (BMI) between 25-35 kg/m²
- •Low physical activity levels or sedentary lifestyle based on the World Health Organization 2020
- •The levels of moderate-intensity physical activity < 150-300 minutes per week or the levels of vigorous-intensity physical activity < 75-150 minutes per week
- •Moderate-intensity physical activity: fast walking and bicycling. Vigorous-intensity physical activity: running, aerobic dance, and swimming All participants are required to meet all inclusion criteria to be eligible for the research project.
排除标准
- •Smoking, substance abuse, or alcohol addiction
- •History of respiratory diseases, such as asthma, emphysema, or chronic obstructive pulmonary disease
- •History of cardiovascular diseases, such as coronary heart disease, aortic disease, arrhythmia, or deep vein thrombosis
- •History of high blood pressure (hypertension)
- •History of vestibular system diseases, such as Meniere's disease or otitis media
- •History of neurological disease, such as severe Parkinson's disease or stroke
- •History of previous lower limb surgery, such as hip, knee, or ankle replacement
- •History of musculoskeletal diseases, such as severe osteoarthritis
- •History of severe brain disease, such as dementia
- •Severe visual or hearing impairment
- •Have a cognitive and comprehensive impairment and unable to complete the intervention
- •Have high physical activity or regularly exercise
结局指标
主要结局
Blood component assessment
时间窗: Pre-training (Day 1 before HIIT program) and post-training (Day 18 after HIIT program within 1 hour)
Participant's blood components, e.g. extracellular vesicles, will be investigated by cell assays and proteomic analysis
Foot pressure distribution
时间窗: 8 times: Day 1 (Before and after HIIT program), Day 4-7 (after HIIT program only), Day 18 (Before and after HIIT program)
Foot pressure distribution will be measured using a treadmill (Zebris FDM-T Treadmill System, zebris Medical GmbH, Germany)
Facial and abdominal fat thickness measurement
时间窗: Pre-training (Day 1 before HIIT program) and post-training (Day 18 after HIIT program)
Facial and abdominal fat thickness and characteristics will be pictured and analyzed using ultrasound imaging
VO2max
时间窗: Pre-training (Day 1 before HIIT program) and post-training (Day 18 after HIIT program)
VO2max parameter (ml/kg/min) will be examined using Cardio Pulmonary Exercise Test
Body composition
时间窗: Pre-training (Day 1 before HIIT program) and post-training (Day 18 after HIIT program)
Body composition (%) will be measured by bioelectrical impedance analysis.
Heart rate
时间窗: Pre-training (Day 1 before HIIT program) and post-training (Day 18 after HIIT program)
Heart rate (beat/min) will be measured by pulse oximeters
Grip strength
时间窗: Pre-training (Day 1 before HIIT program) and post-training (Day 18 after HIIT program)
Grip strength (kg) will be measured by hand grip dynamometer
Leg strength
时间窗: Pre-training (Day 1 before HIIT program) and post-training (Day 18 after HIIT program)
Leg strength (kg) will be measured by back-leg-chest dynamometer
Body weight
时间窗: Pre-training (Day 1 before HIIT program) and post-training (Day 18 after HIIT program)
Body weight (kg) will be measured by weighing scale
Body height
时间窗: Pre-training (Day 1 before HIIT program)
Body height (cm) will be measured by stadiometer
次要结局
未报告次要终点