IRCT20190810044500N2招募中2 期
Evaluation of effects of oral medroxyprogesterone and donepezil in improvement of respiratory status and facilitation in weaning of mechanical ventilation in patients undergoing mechanical ventilation in ICUs of Shahid Dr. Rahnemoon Yazd
Yazd University of Medical Sciences0 个研究点目标入组 45 人开始时间: 待定最近更新:
适应症
试验速览
- 阶段
- 2 期
- 状态
- 招募中
- 发起方
- 入组人数
- 45
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
- 年龄范围
- 18 years 至 no limit（—）
- 性别
- All
入选标准
- •Mechanical ventilation through endotracheal tube for at least 24 hours
- •oxygen saturation greater than 90%
- •FIO2 less than 50%
- •PEEP less than 8 cm water
- •hemodynamic stability over the past 12 hours
- •sedation withdrawal or sedation reduction Over the past 48 hours
- •neurological status stabilized with Ramsay's score less than 5
- •temperature between 36 and 39 degrees
排除标准
- •Pregnancy or lactation
- •under 18 years of age
- •tracheostomy
- •hepatic encephalopathy
- •cerebral edema
- •acute hydrocephalus
- •myasthenia gravis
- •Acute polyneuropathy
- •lack of decision to discontinue respiratory support
- •prolonged cardiac arrest with poor neurologic prognosis
- •coincident extubation with day one
- •acute right ventricular failure
- •renal failure
- •plasma urea exceeding (25 mol / L), Plasma creatinine greater than (180 mol / min) or creatinine clearance less than 30 ml / min, or more than 25% increase in creatinine over the past 24 hours
- •contrast injection over the past six hours
- •Serum sodium level greater than (150 m Eq) / L
- •serum potassium level less than 3.5 (m Eq) / L
- •metabolic alkalosis with arterial pH greater than 7.5
- •need for sedation or unconsciousness
- •concurrent administration of drugs Potential respiratory stimulants such as doxapram and medroxyprogesterone
- •hypothyroidism
- •Known allergy to donepezil or medroxy progesterone
研究者
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