The Acute Effects of Diazepam on Blood Pressure Regulation
试验速览
- 阶段
- 早期 1 期
- 状态
- 已完成
- 发起方
- 入组人数
- 40
- 试验地点
- 1
- 主要终点
- Resting beat-to-beat blood pressure variability
研究概览
简要总结
The aim of this study is to determine the acute effects of diazepam on beat-to-beat blood pressure variability and baroreflex control.
详细描述
Benzodiazepines are widely prescribed for a variety of clinical conditions. However, its cardiovascular consequences remain controversial. In this study, the investigators sought to determine the acute effects of a single dose of oral diazepam (10mg) on resting beat-to-beat blood pressure variability and cardiac and sympathetic baroreflex sensitivity in a cohort of young, healthy individuals.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 18 Years 至 40 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •18 to 40 years of age
- •Healthy, free of known cardiovascular, metabolic, or musculoskeletal disease
排除标准
- •History of smoking (tobacco or cannabis), defined as any smoking within the past 3 months
- •Diagnosed cardiovascular or metabolic disease(s)
- •Prescription of chronic medications other than oral contraceptives
- •History of hypertension or presence of arrhythmia
研究组 & 干预措施
Diazepam
Oral
干预措施: Diazepam (Drug)
Placebo
Oral
干预措施: Diazepam (Drug)
结局指标
主要结局
Resting beat-to-beat blood pressure variability
时间窗: Change from baseline at 60 min
Finger photoplethysmography
Systolic and diastolic blood pressure
时间窗: Change from baseline at 60 min
Oscillometric device
次要结局
- Muscle sympathetic nerve activity(Change from baseline at 60 min)
- Baroreflex sensitivity(Change from baseline at 60 min)