Comparative efficacy of mycophenolate mofetil and clobetasol propionate for the treatment of oral erosive lichen planus

20 subjects, referred to the Department of Oral Medicine will be evaluated by the investigator based on modified WHO criteria for erosive oral lichen planus (OLP)diagnosis (Van der Meij & Van der Waal, 2003), will be included. 10 patients with bilateral OLP receiving mycophenolate mofetil will be included in Group A and 10 patients with OLP receiving clobetasol will be included in (Group B).In Group A, the patients will be instructed to place 2% Mycophenolate mofetil (MMF) mucoadhesive on lesions Thrice daily (morning, afternoon and at night) after taking food, for 4 weeks(first visit,2nd week,3rd week and fourth week from first day). Neither patients nor investigator will be aware of which medication is being administered. In Group B, the patients will be using 0.05% Clobetasol propionate on the lesion thrice daily (morning and afternoon, night), for 4 weeks (first visit,2nd week,3rd week and fourth week from first day). All the patients will be instructed to breathe through the mouth before drug use to make the surface dry and then place the mucoadhesive on the lesion and wait for 1 min for its attachment. The patients will be asked to avoid eating, drinking and mouth washing for at least 10–15 min. They are also asked about drug compliance and side effects of gastrointestinal system, rash, fever, and headache each week(4 visits) and by phone calls between weekly visits.On every first visit,VAS score and reduction of lesion size will be recorded and data will be analysed and compared to assess the efficacy of both the topical ointments and also to compare the efficacy of both the ointments by using statistical tests.