Does Brain Functions Depend on Omega 3 Transferred to the Fetus During the Intra Uterine Life ?
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 46
- 主要终点
- Change in neurodevelopment
研究概览
简要总结
The purpose of this study is to evaluate the feasibility of using a quantitative EEG method to evaluate neurodevelopment in newborns and to evaluate whether subtle neurodevelopmental deficits can be detected in newborns from mothers with gestational diabetes mellitus (GDM) compared to control newborns.
The second purpose of this study is to determine whether cord blood concentration in docosahexaenoic acid (DHA), an omega-3 fatty acid, is similar in neonates of well-controlled mothers with gestational diabetes mellitus (GDM) compared to control mothers, and to evaluate whether this contributes to neonates neurodevelopment status.
详细描述
Maternal weight is measured close to delivery and BMI is calculated. Birth weight, length, head circumference, Apgar score and glycaemia are recorded at birth. An EEG are performed on the newborn within 48 hrs after birth.A maternal blood sample is collected at admission to measure maternal glycated hemoglobin (A1C). Cord blood samples are collected in the umbilical vein after delivery.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 40 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •singleton pregnancy
- •aged between 18 and 40 years
排除标准
- •illicit drug consumption,
- •omega-3/6 consumption,
- •liver or renal disease,
- •any medical conditions affecting glucose/lipid metabolism.
结局指标
主要结局
Change in neurodevelopment
时间窗: At birth
Evaluate change in neurodevelopment with GDM
次要结局
- Change in DHA level in cord blood(At birth)
研究者
Mélanie Plourde
PhD
Université de Sherbrooke