Pain Management After Total Knee Arthroplasty: Incidence and Outcomes of Rebound Pain
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 300
- 试验地点
- 1
- 主要终点
- Incidence of Rebound Pain After Peripheral Nerve Block
研究概览
简要总结
This prospective observational study aims to determine the incidence and clinical impact of rebound pain after peripheral nerve blocks in patients undergoing total knee arthroplasty. Rebound pain is defined as a sudden, severe pain (NRS ≥7) emerging after block resolution. Primary outcome is the incidence of rebound pain; secondary outcomes include pain severity, rescue analgesia use, nausea, vomiting, sleep quality, and patient satisfaction.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age between 18 and 70 years
- •ASA physical status I to III
- •Scheduled for elective unilateral total knee arthroplasty under spinal anesthesia
- •Peripheral nerve block (PNB) planned as part of multimodal analgesia
- •Ability to understand and provide written informed consent
- •Willingness and ability to complete the postoperative pain diary
排除标准
- •Known allergy or hypersensitivity to local anesthetics
- •Contraindication to regional anesthesia
- •ASA physical status IV or higher
- •Neurological or psychiatric disorders interfering with study participation or pain reporting
- •Use of anticoagulants or presence of coagulopathy
- •Use of medications that may alter pain perception or rebound pain response
- •Local infection at the block site
- •Emergency surgeries
- •Inability or unwillingness to complete the postoperative pain diary or follow-up
结局指标
主要结局
Incidence of Rebound Pain After Peripheral Nerve Block
时间窗: Within 48 hours after surgery
Rebound pain is defined as a sudden, severe increase in pain occurring after the resolution of peripheral nerve block, typically within 12-24 hours postoperatively. Pain intensity will be assessed using the Numeric Rating Scale (NRS; 0 = no pain, 10 = worst imaginable pain). A score of NRS ≥7 will be considered as severe pain. Patients will record pain scores in a pain diary, and incidence will be calculated as the proportion of patients meeting the rebound pain criteria.
次要结局
- Sleep Quality(From 1 day before surgery to postoperative day 7)
- Patient Satisfaction with Pain Management(Postoperative day 7 (via telephone follow-up))
- Total Rescue Analgesic Consumption(Within 48 hours after surgery)
- Time to First Rescue Analgesia(Within 48 hours after surgery)
研究者
Mahmut Sami TUTAR
Associate Professor, Department of Anesthesiology and Reanimation
Konya City Hospital