Can 10 Seconds Inspiratory Hold Open Atelectasis in Mechanically Ventilated Patients? A Pilot Study.
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 12
- 试验地点
- 1
- 主要终点
- Ventilation in previously non-ventilated lung tissue
研究概览
简要总结
This study evaluates whether sustaining inspiratory pressure for 10 seconds at a time can open collapsed lung areas in non-dependant regions of the lung in mechanically ventilated patients.
详细描述
Collapse of lung volume, atelectasis, is a common complication in sedated and mechanically ventilated patients. In adults the atelectasis occur mainly in the dependant areas of the lung. In this study the investigators examine whether these atelectasis can be opened by repeatedly sustaining the inspiratory pressure for 10 seconds when the patient has been positioned so that the atelectasis is located in a non-dependant position. Furthermore, the investigators examine how many times the inspiratory pressure needs to be sustained before the atelectasis is opened and at what pressure.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Continuously or intermittently mechanically ventilated with artificial airway (endotracheal tube or tracheostomy tube)
- •Pressure controlled or pressure supported ventilator mode
- •PEEP ≤ 12 cm H2O, registered peak pressure ≤ 32 cm H2O
- •Non-ventilated lung regions according to E.I.T. measurements
- •Richmond Agitation Score 0 -(-5)
- •Circulatory stable or stabilized
排除标准
- •Pregnancy
- •BMI > 50
- •Pacemaker or other electrically active implants
- •Skin lesions, wounds or bandages on chest area where E.I.T. belt needs to be placed
- •Undrained pneumothorax
- •Pulsating air-mattress
- •Unstable skeletal injury to spinal column
- •Recent brain injury or spinal chord injury
- •Recent injury to heart, to major blood vessels in chest, to major airways or to the oesophagus.
研究组 & 干预措施
Inspiratory hold
Mechanical inspiratory pressure held for 10 seconds at a time.
干预措施: Inspiratory hold (Other)
结局指标
主要结局
Ventilation in previously non-ventilated lung tissue
时间窗: During intervention and for 30 minutes after ended intervention
Registered using electrical impedance tomography, E.I.T., via PulmoVista500 by Dräger Medical
次要结局
未报告次要终点