Quantitative Analysis of 3T Whole Heart Coronary Magnetic Resonance Angiogram Improves Detection of Functionally Significant Coronary Artery Disease
试验速览
- 阶段
- 不适用
- 入组人数
- 89
- 试验地点
- 1
- 主要终点
- Presence of functionally significant coronary stenosis
研究概览
简要总结
This study aims to evaluate whether quantitative analysis of coronary MR angiogram would improve the detection of functionally-significant coronary artery stenosis.
详细描述
Coronary MR angiography is performed with a 3.0-T imager with 32-channel coils. Qunatitative analysis of coronary MR angiogram is evaluated on the basis of the signal intensity (SI) profile along the vessel. Quantitative analysis of coronary MR angiogram (QCMRA) is calculated as [1 - (SImin/SIref)] x 100, where SImin is minimal SI and SIref is corresponding reference SI. Diagnostic performance of quantitative analysis of coronary MR angiogram for predicting functional significant coronary stenosis was evaluated by using fractional flow reserve (FFR) as the reference standard.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age ≥ 18 years
- •1 or more coronary stenoses in the major coronary artery with a vessel diameter ≥ 2mm on coronary MR angiogram
- •Patient who were planned to undergo invasive coronary angiography and fractional flow reserve
排除标准
- •clinically unstable patient
- •a history of coronary revascularization
- •infiltrative cardiomyopathy, hypertropic cardiomyopathy, myocarditis
- •contraindication to use of adenosine
- •complete occlusion of target lesion
结局指标
主要结局
Presence of functionally significant coronary stenosis
时间窗: within 1 month
fractional flow reserve \< 0.8
次要结局
未报告次要终点
研究者
Yeonyee E Yoon, MD
Associate Professor
Seoul National University Bundang Hospital