Interdisciplinary Centenarian and Semi-supercentenarian Study in Japan Part 2: the phenotypic and biomarker signatures for healthy longevity - Japan Centenarian and Semi-supercentenarian Study Part 2 (biomarker study)

In a cohort of 1554 individuals including 684 centenarians and semi-supercentenarians, inflammation predicted all-cause mortality in the very old and semi-supercentenarians. Inflammation predicted capability and cognition in (semi-)supercentenarians, suggesting suppression of age-related inflammatory activation is the key to healthy longevity.