Assessment of Coronary Endothelial Function and Myocardial Fibrosis in Positron Emission Tomography With the Waning of Acute Coronary Syndrome With Elevated ST Segment : Relationship With Left Ventricular Remodeling
试验速览
- 阶段
- 不适用
- 状态
- 终止
- 入组人数
- 30
- 试验地点
- 2
- 主要终点
- Measurement of fibrosis
研究概览
简要总结
Left ventricular remodeling is a common complication in patients with ST-elevation myocardial infarction (STEMI ) and may lead to heart failure. Hemodynamic, metabolic and inflammatory mechanisms are involved in this pathophysiological process. Recent data demonstrated that remote, noninfarct-related region of the myocardium is also implicated. There is no data about the assessment of coronary endothelial function or myocardial fibrosis in the remote zone in patients with STEMI . The correlation between these parameters and left ventricular remodeling is not known.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Other
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •First ST Elevation Myocardial Infarction
- •Primary Percutaneous Coronary Intervention (TIMI 3)
- •Single vessel coronary artery disease
- •Age over 18 years
- •Informed Consent dated and signed
- •Written and spoken French
- •Beneficiary of social security insurance
排除标准
- •No Primary Percutaneous Coronary Intervention
- •TIMI 0-2 after Primary Percutaneous Coronary Intervention
- •Significant two or three-vessel coronary artery disease (> 70% stenosis in at least one of the other two coronary arteries)
- •Past history of myocardial infarction before STEMI
- •Mechanical complication (ischaemic mitral regurgitation, interventricular septal defect, cardiac tamponade) or clinical signs of heart failure
- •Pregnant and / or lactating
- •Age under 18 years or guardianship
研究组 & 干预措施
STEMI
All patients included in this study (1 arm)
干预措施: (15)-O water positron emission tomography and Biomarkers (Other)
结局指标
主要结局
Measurement of fibrosis
时间窗: 3 months
3 months following an acute coronary syndrome STEMI an ST segment (segments in myocardial infarcted area and "remote" ) .
Measurement of coronary endothelial function
时间窗: 3 months
3 months following an acute coronary syndrome STEMI an ST segment (segments in myocardial infarcted area and "remote" ) .
次要结局
- Correlating biomarkers with local and global parameters of coronary endothelial function , inflammation and myocardial fibrosis with early echocardiographic parameters of left ventricular remodeling and cardiac magnetic resonance imaging(3 months)