NCT03777943已完成不适用
Role of the Peritoneal Microenvironment in the Pathogenesis and Spread of Colorectal Carcinomatosis
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 53
- 试验地点
- 1
- 主要终点
- Immunohistochemistry (IHC) analysis
研究概览
简要总结
The goal of this project is to investigate the extent and role of mesothelial - mesenchymal transition (MMT) and cancer associated fibroblasts (CAFs) in the pathogenesis of colorectal peritoneal carcinomatosis (PC).
研究设计
- 研究类型
- Observational
- 观察模型
- Other
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients presenting with colorectal peritoneal carcinomatosis
排除标准
- •Pregnancy or breast feeding
- •Psychiatric pathology capable of affecting comprehension and judgment faculty
- •HIPEC (hyperthermic intraperitoneal chemotherapy) or PIPAC (pressurized intraperitoneal aerosol chemotherapy) in the past
- •Abdominal radiation treatment
结局指标
主要结局
Immunohistochemistry (IHC) analysis
时间窗: Within 6 months after collection of the samples
Extensive IHC analysis will be performed including CD44, integrins, ICAM-1, hyaluronate, and VCAM-1 (adhesion molecules); calretinin, mesothelin, WT1, cytokeratins and E-cadherin (mesothelial markers); α-SMA, FAP and podoplanin (CAF specific markers); PDGF, VEGF and EDGF (angiogenesis related markers)
次要结局
- Intra-tumoral versus peritoneal vascularity(Within 6 months after collection of the samples)
- Laser capture microdisssection (LCM) followed by gene expression analysis(Within 12 months after collection of the samples)
研究者
GIHeelkunde
Principle investigator
University Hospital, Ghent
研究点 (1)
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