NCT01064011Unknown不适用
A Prospective Randomized, Controlled Trial for Treatment of Intraventricular Hemorrhage: External Ventricular Drainage and Intraventricular Thrombolysis vs. External Ventricular Drainage and Endoscopic Evacuation
适应症
试验速览
- 阶段
- 不适用
- 入组人数
- 34
- 试验地点
- 2
研究概览
简要总结
Intraventricular hemorrhage comprises about 15% of the 500,000 strokes that occur annually in the United States. In the emergent setting, patients with obstructive hydrocephalus are routinely treated with placement of an external ventricular drain. This study will compare the effect of external ventricular drainage plus intraventricular thrombolysis versus external ventricular drainage plus endoscopic evacuation on neurologic outcomes for patients with hydrocephalus from intraventricular hemorrhage.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 75 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age 18-75
- •Radiographic evidence of intraventricular hemorrhage with hydrocephalus
- •Admission Glasgow Coma Scale ≥ 5 (motor score ≥ 2)
- •Placement of an external ventricular drain with an opening pressure >20 mm Hg
排除标准
- •Intraventricular hemorrhage secondary to cerebral aneurysm, arteriovenous malformation, or tumor
- •Coagulopathy (Platelet count <100,000, International normalized ratio >1.
- •Reversal of warfarin is permitted.)
- •Age <18 or >75
- •Pregnancy (positive pregnancy test)
- •Clotting disorders
- •Medical contraindications to administration of general anesthesia as determined by the attending anesthesiologist
- •Medical contraindications to surgery as determined by the attending neurosurgeon
- •Contraindication to recombinant tissue plasminogen activator administration:
- •Evidence of enlargening intracranial hemorrhage as evidenced by an increase in intracranial hemorrhage volume (>5 ml) on CT obtained after EVD placement
- •Internal bleeding, involving retroperitoneal sites, or the gastrointestinal, genitourinary, or respiratory tracts
- •Superficial or surface bleeding, observed at vascular puncture and access sites (e.g. venous cutdowns, arterial punctures) or site of recent surgical intervention
- •Evidence of cerebrospinal infection by Gram stain or culture
- •Advanced directive indicating Do Not Resuscitate or Do Not Intubate status
研究者
研究点 (2)
Loading locations...
相似试验
进行中（未招募）
不适用
Efficacy of Recreational-therapeutic Use of Video Games on the Emotional State of Stroke PatientsStroke, AcuteVirtual RealityNCT05143385Hospital San Carlos, Madrid94
招募中
4 期
International Care Bundle Evaluation in Cerebral Hemorrhage ResearchIntracerebral HemorrhageIntracerebral HaemorrhageIntraventricular HemorrhageStrokeCerebrovascular DiseaseNCT06429332Region Skane3,500
撤回
不适用
Randomized Study Comparing Periodic Acceleration Versus Static Position in Cerebrovascular Stroke PatientsCerebrovascular StrokeNCT02038998Fundacion Rioja Salud
已完成
不适用
Stroke Research Consortium in Northern Bavaria (STAMINA)Ischemic StrokeNCT04357899University of Erlangen-Nürnberg Medical School3,769
Unknown
2 期
Remote Ischemic Conditioning Paired With Endovascular Treatment for Acute Ischemic StrokeAcute StrokeNCT03045055Capital Medical University180