NCT00833508已完成不适用
Effect of Preoperative Chemoradiotherapy on Exercise Capacity as Measured by Cardiopulmonary Exercise Testing
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 40
- 试验地点
- 2
- 主要终点
- Change of Anaerobic threshold of 1.5ml/min/kg or more
研究概览
简要总结
This study will investigate the effect of preoperative chemoradiotherapy on exercise capacity as measured by cardiopulmonary exercise testing in patients with colorectal cancer.
详细描述
Chemoradiotherapy is associated with adverse effects. Patients with certain colorectal cancers undergo chemoradiotherapy prior to surgical resection. We intend to assess patient exercise capacity before and after chemoradiotherapy to assess whether this deteriorates. If there is a deleterious effect, this may affect operative outcome.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Diagnostic
- 盲法
- None
入排标准
- 年龄范围
- 65 Years 至 —（Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age greater than 65
- •Colorectal cancer requiring preoperative chemoradiotherapy
排除标准
- •Inability to walk, or exercise on a bicycle or treadmill
- •Inability to understand instructions for CPET testing
- •ASA grade 4 or 5 (indicating severe cardiovascular co-morbidity and not expected to survive surgery)
- •Contraindications to Exercise Testing
- •Myocardial infarction occurring 10 days or less before CPX testing
- •Symptomatic arrythmias
- •Left Main Stem coronary disease of >50%
- •Severe hypertension (SBP>180mmHg)
- •Resting SpO2 <85%
- •Acute cardiac inflammatory conditions (myocarditis, pericarditis)
- •Unstable angina with symptoms within 4 days
- •Dissecting aneurysm of aorta
- •Acute pyrexial illness
- •Thyrotoxicosis
- •Syncopal episodes
- •Lower limb thrombosis (arterial or venous)
结局指标
主要结局
Change of Anaerobic threshold of 1.5ml/min/kg or more
时间窗: 6 weeks
次要结局
- Operative outcome(6-10 weeks)
研究者
研究点 (2)
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