Growth Hormones and Cells in Human Milk Depending on Gestational Age and Lactation Phase
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 43
- 试验地点
- 1
- 主要终点
- neurotrophins composition
研究概览
简要总结
Human breast milk contains growth factors including neurotrophins and cells with neuroprotective potential. Concerning growth factors milk of preterms differs significantly from term milk. The aim of this study is to give a profile of human milk concerning non-nutritive factors depending on gestational age and lactation phase.
详细描述
Neurotrophins (epidermal growth factor (EGF), vascular endothelial growth factor (VEGF), nerve growth factor (NGF), brain derived neurotrophic factor (BDNF)) as well as amount of cells, especially positive for sex-determining transformer protein (TRA)-1-81 and stage-specific embryonic antigen (SSEA)-4, are planned to be quantified in human breast milk of extremely preterm newborns as well as term newborns at different stages of lactation.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •the newborn infant is being fed with own mothers milk
排除标准
- •low amount of breast milk
结局指标
主要结局
neurotrophins composition
时间窗: day 7
Concentration of Neurotrophins EGF, VEGF, NGF, BDNF in the human milk
次要结局
- Amount of cells positive for surface markers TRA-1-81 and SSEA-4(day 7)
研究者
Titus Keller, MD
Neonatologist
University Hospital of Cologne