Words on the Brain: Can Reading Rehabilitation for Age-Related Vision Impairment Improve Cognitive Functioning?
试验速览
- 阶段
- 不适用
- 状态
- 终止
- 入组人数
- 38
- 试验地点
- 4
- 主要终点
- Letter Number Sequencing task
研究概览
简要总结
Age-related vision impairment and dementia both become more prevalent with increasing age. Research into the mechanisms of these conditions has proposed that some of their causes (e.g., macular degeneration/glaucoma and Alzheimer's disease) could be symptoms of an underlying common cause, or may be equally linked to a multifactorial context in frailty and aging. Research into sensory-cognitive aging has provided preliminary data that sensory decline may be linked to the progression of dementia through the concept of sensory deprivation. Preliminary data in hearing loss rehabilitation support the idea that improved hearing may have a beneficial effect on cognitive functioning; however, there are to date no data available to examine whether low vision rehabilitation, specifically for reading, could have an equally protective or beneficial effect on cognitive health. The present proposal aims to fill this gap.
详细描述
The research questions are the following:
- Does low vision rehabilitation reduce reading effort?
- If so, does reduced reading effort increase reading activity,
- If so, does increased reading activity improve cognitive (memory) functioning?
The objectives are to:
- Evaluate cognitive functioning and memory before, and 6 and 12 months after low vision reading rehabilitation using magnification in patients with age-related macular degeneration or glaucoma, compared to age-matched visually impaired controls who undergo rehabilitation that is NOT related to reading (e.g., mobility)
- Correlate participant characteristics with all cognitive outcome variables in order to identify potential mediators, moderators or confounders
Hypotheses:
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 65 Years 至 —（Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Able to communicate in either English or French
- •Impairment of central vision, affecting acuity due to any diagnosis
- •Visual acuity in the better eye with best standard correction of 20/60 or less
- •Potential benefit from magnification or other reading rehabilitation interventions, as determined by rehabilitation professional.
- •Client dossier with one of the partnering rehabilitation agencies.
排除标准
- •Complete blindness
- •Inability to communicate verbally
- •Inability to independently give informed written consent
结局指标
主要结局
Letter Number Sequencing task
时间窗: 2 minutes
Participants are asked to speak out loud the first 13 letters of the alphabet and alternate them with consecutive numbers (e.g., 1 - A - 2 - B 3 -C ...). The score is the number of correct alternations between numbers and letter, from 0 to 26, with higher scores indicating better performance.
Rey Auditory Verbal Learning Test (RAVLT)
时间窗: 15 minutes
Participants are verbally presented with a list of 15 words that they are asked to repeat and memorize, then recall immediately, and again recall them 15 minutes later. The score is the number of items recalled from 0 to 15, with higher scores indicating better recall.
Montreal Cognitive Assessment - full or blind version
时间窗: 4 minutes
Participants are asked to complete the visual and auditory items of this cognitive screening measure. The Blind versions (no visual items is utilized for persons whose vision is too impaired to see the pictograms). The score is the total number of items completed correctly, ranging from 0 to 30 for the full version, and 0 to 22 for the Blind version, with higher scores indicating better outcomes
1-n-back task
时间窗: 3 minutes
Participants are asked to verbally repeat a string of numbers presented orally, while naming the previous item to the one just presented. The score is the total number of correct recalls, ranging from 0 to 25, with higher scores indicating better performance.
次要结局
- Minnesota Reading Test (MNRead)(2 minutes)
- Magnetic Resonance Imaging (MRI) - for subset of participants(45 minutes)
- Depression, Anxiety and Stress Scale(5 minutes)
- Canadian Digit Triplet Test(4 minutes)
研究者
Walter Wittich
Assistant Professor
Université de Montréal