State Dependence of Prefrontal Transcranial Magnetic Stimulation
试验速览
- 阶段
- 4 期
- 状态
- 已完成
- 入组人数
- 51
- 试验地点
- 2
- 主要终点
- Theta-gamma cross frequency coupling
研究概览
简要总结
The study will examine whether the benefits of brain stimulation on mental functioning can be enhanced if an individual is actively engaging the target brain networks while receiving brain stimulation. The study includes two separate sessions and people will complete either a cognitive task or a perceptual task while receiving transcranial magnetic stimulation. The study will measure change in brain function with EEG.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- None
盲法说明
No blinding is possible
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Age 18 - 65,
- •healthy controls
排除标准
- •Diagnosed psychiatric disorder
- •Potential contraindications to EEG (e.g. visible scalp abrasions, non-removable hair extensions and/or hair styling that would impede proper EEG recording)
- •Potential contraindication to TMS (as identified by the TMS safety screener)
- •Any previous adverse reaction to TMS or MRI
- •Diagnosed epilepsy or previously experienced a seizure
- •Diagnosed neurological condition, such as stroke or tinnitus
- •Experienced a head trauma that was diagnosed as concussion
- •Current use of, or recent withdrawal from, medications that can increase the risk of seizure
- •Currently pregnant
- •Any metal in the head (excluding mouth)
- •Any implanted medical device
结局指标
主要结局
Theta-gamma cross frequency coupling
时间窗: 0-500 ms after each TMS stimulus
A metric of brain function measured with EEG - the coupling of theta oscillation phase with gamma power. This will be measured immediately following the intervention (TMS stimulation).
Cortical excitability
时间窗: 60-300 ms after each TMS stimulus
TMS-evoked potentials will be measured with EEG to examine cortical excitability after TMS. This will be measured immediately following the intervention (TMS stimulation).
次要结局
未报告次要终点